The therapeutic value of HPA-1a-negative platelet transfusion in post-transfusion purpura complicated by life-threatening haemorrhage.

Vox Sanguinis
N WinW H Watson

Abstract

Post-transfusion purpura (PTP) was diagnosed in a female patient 1 week after transfusion for hysterectomy. Despite treatment with oral steroids and intravenous immunoglobulin, platelet counts remained low, and the patient developed profuse rectal bleeding. Random platelet transfusion is reported to be ineffective in PTP. We report a case in which the transfusion of HPA-la negative platelets provided good increment and clinical haemostasis before intravenous immunoglobulin could have had an effect.

References

Jul 1, 1989·British Journal of Haematology·A C Newland
Jun 1, 1989·Blood Reviews·A H Waters
Jun 1, 1986·The Science of the Total Environment·P C Elwood
Nov 1, 1986·British Journal of Haematology·C Mueller-Eckhardt
Sep 1, 1985·British Journal of Haematology·T BeckerC Mueller-Eckhardt

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Citations

Feb 9, 1999·Blood Reviews·B J Hunt
Jul 1, 1997·Journal of Veterinary Internal Medicine·K J WardropM Buss
Apr 17, 2016·Lancet·Meghan DelaneyUNKNOWN Biomedical Excellence for Safer Transfusion (BEST) Collaborative
Jun 30, 2004·American Journal of Hematology·Alison Wakoff Loren, Charles S Abrams
Apr 15, 2000·Journal of Clinical Apheresis·K M Grima

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