The thickness and volume of LLETZ specimens can predict the relative risk of pregnancy-related morbidity

BJOG : an International Journal of Obstetrics and Gynaecology
S KhalidWalter Prendiville

Abstract

The aim of this study was to determine if the individual physical characteristics of the extirpated transformation zone after large loop excision of the transformation zone (LLETZ) might predict the relative risk of adverse obstetric outcome, specifically preterm labour (PTL). A retrospective observational study. University teaching hospital in Dublin (Coombe Women & Infants University Hospital, CWIUH). Women who had LLETZ treatment for cervical intraepithelial neoplasia (CIN) in the colposcopy service between 1999 and 2002, and who subsequently had a pregnancy at the CWIUH. Case records and histology reports for eligible women were examined. Age, parity, smoking history, pregnancy complications and CIN grade were recorded. Exclusion criteria were age >42 years, previous treatment for CIN, previous premature labour or twin pregnancies. The Student's t-test, Mann-Whitney U-test, analysis of variants (ANOVA) and logistic regression were employed to analyse the data. Gestational age at birth, PTL (i.e. <37 weeks of gestation) and miscarriage rate (<24 weeks of gestation). Out of 1808 women who underwent LLETZ treatment, a total of 353 women were identified who subsequently had a pregnancy at the CWIUH, with 321 being eligible for ...Continue Reading

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Citations

May 8, 2013·Archives of Gynecology and Obstetrics·Christoph GrimmStephan Polterauer
May 15, 2013·Archives of Gynecology and Obstetrics·Xavier CarcopinoWalter Prendiville
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