The thickness of the A1 pulleys reflects the disability of hand mobility in scleroderma. A pilot study using high-frequency ultrasound

European Journal of Radiology
Alberto TagliaficoCarlo Martinoli

Abstract

Hand involvement in scleroderma is a serious concern. Clinical tests to asses hand dysfunction are based on the experience of the clinician. To asses if utrasonographic (US) measurement of A1 pulley thickness may be used as an indicator of hand mobility in scleroderma. Institutional review board approval and patient informed consent was obtained. Twenty-eight patients affected suffering from scleroderma and 40 healthy controls were prospectively evaluated by two blinded radiologists with US, with a transducer operating at 17MHz. A1 pulley thickness was measured and correlated with the Hand Mobility in Scleroderma Test (HAMIS) and disease duration. The thickness of the A1 pulley was greater in sclerodermic patients than in controls (p < 0.05). Intra and inter-observer agreement were better for ultrasound (0.94;0.88) than for HAMIS tests (0.71;0.70). A good correlation between pulley thickness, hand mobility and disease duration was found (r = 0.78, p < 0.018; r = 0.54, p < 0.05). A1 pulley thickness measured on ultrasound correlates with hand mobility and disease duration. Ultrasound is an useful tool to evaluate hand disability in scleroderma.

References

Apr 1, 1982·Annals of the Rheumatic Diseases·M BaronE C Keystone
Nov 26, 2003·Arthritis Care and Research : the Official Journal of the Arthritis Health Professions Association·G Sandqvist, M Eklund
May 28, 2004·Scandinavian Journal of Rheumatology·G SandqvistU Nordenskiöld
Aug 2, 2005·Nursing Forum·Irene Gilliland
Oct 6, 2006·European Radiology·Nathalie BoutryAnne Cotten
Apr 9, 2008·Annals of the Rheumatic Diseases·G A W BruynW A Schmidt
Sep 29, 2009·European Journal of Radiology·Alberto TagliaficoCarlo Martinoli

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Citations

Jan 15, 2011·Clinical Rheumatology·Suzanne L DeLeaArthur D Bankhurst
Dec 19, 2012·Rheumatology·Francesco PortaMarco Matucci-Cerinic
Feb 19, 2014·Clinical Rheumatology·Marwin GutierrezWalter Grassi
Nov 29, 2013·Connective Tissue Research·Johanna BuschmannMaurizio Calcagni
Feb 3, 2016·Ultrasound in Medicine & Biology·Tai-Hua YangFong-Chin Su
May 31, 2013·Rheumatic Diseases Clinics of North America·Russell Chapin, Faye N Hant
Jan 22, 2013·Arthritis Care & Research·Muriel ElhaiYannick Allanore
Sep 7, 2013·Radiology·Véronique FreireHenri Guérini
Apr 30, 2016·Ultrasound in Medicine & Biology·Andres SpirigEsther Vögelin
Dec 7, 2011·Arthritis and Rheumatism·Giovanna CuomoGabriele Valentini
Jan 22, 2013·Arthritis Care & Research·Francesca Ingegnoli, Giovanna Cuomo
Jan 16, 2021·Journal of Clinical Medicine·Katarzyna RutkaUrszula Łebkowska

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