The thickness of the intestinal mucous layer in the colon of rats fed various sources of non-digestible carbohydrates is positively correlated with the pool of SCFA but negatively correlated with the proportion of butyric acid in digesta

The British Journal of Nutrition
M S HedemannK E Bach Knudsen

Abstract

The present experiment aimed to study the influence of six sources of non-digestible carbohydrates (NDC) on the mucous layer in the colon of rats. The NDC sources used were as follows: cellulose (C); pectin (P); inulin; resistant starch (RS); barley hulls. The diets contained 108-140 g NDC/kg DM. A fibre-free (FF) diet served as a control. The diets were fed to forty-eight rats for 34-41 d. The thickness of the total mucous layer in the colon was increased (P < 0.05) in rats fed C, P and RS when compared with rats fed a FF diet. In the colon, positive correlations were observed between the total thickness of the mucous layer and the area of neutral mucins, the pool of SCFA and the pool of acetic acid, while it was negatively correlated with the proportion of butyrate. The total thickness of the mucous layer was not correlated with the MUC gene transcription. The transcription of the gene MUC2 was negatively correlated (P = 0.04), whereas the transcription of MUC3 was positively correlated (P = 0.05) with the butyrate pool in the caecum. No correlations between the MUC2 or MUC3 transcription and SCFA were found in the colon. Hence, the regulation of the MUC genes differs between the compartments of the hindgut and, within compar...Continue Reading

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Citations

Aug 3, 2010·The British Journal of Nutrition·Carlos A MontoyaJean-Paul Lallès
Oct 31, 2012·The British Journal of Nutrition·Daniel Columbus, Cornelis F M de Lange
Dec 30, 2014·Nutrients·Michael A Conlon, Anthony R Bird
Apr 13, 2010·The Veterinary Journal·Gerard HuyghebaertFilip Van Immerseel
Jul 23, 2014·Journal of Food Science·Gunaranjan PaturiJuliet Ansell
Jul 21, 2016·Critical Reviews in Food Science and Nutrition·Mengfei Peng, Debabrata Biswas
Apr 11, 2017·European Journal of Nutrition·Maria Gabriella Gabrielli, Daniele Tomassoni
Sep 1, 2017·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Akihito Harusato, Benoit Chassaing
Nov 9, 2018·Molecular Nutrition & Food Research·Richard You WuPhilip M Sherman
Feb 13, 2019·Alimentary Pharmacology & Therapeutics·John O'GradyFergus Shanahan
Apr 4, 2019·Journal of Animal Physiology and Animal Nutrition·Ewa ŚwięchEwelina Siwiak
Mar 4, 2020·Nutrients·Michael A ConlonMahinda Y Abeywardena
Sep 20, 2011·Journal of Animal Science·T E Weber, B J Kerr
Dec 24, 2018·PloS One·Taylor L CarlsonRebecca L Carrier
Oct 17, 2018·Nutrients·Knud Erik Bach KnudsenKjeld Hermansen
Oct 30, 2020·Critical Reviews in Food Science and Nutrition·Rosângela Dos Santos FerreiraOctávio Luiz Franco
Dec 2, 2020·Animals : an Open Access Journal From MDPI·Marta KubiśSebastian A Kaczmarek
Sep 1, 2019·Comprehensive Reviews in Food Science and Food Safety·Jiefen CuiJinkai Zheng
Nov 12, 2020·International Journal of Molecular Sciences·Agata BiniendaMaciej Salaga
Nov 20, 2020·Nature Reviews. Gastroenterology & Hepatology·Samantha K GillKevin Whelan

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