The THINC-it Tool for Cognitive Assessment and Measurement in Major Depressive Disorder: Sensitivity to Change

Frontiers in Psychiatry
Roger S McIntyreRodrigo B Mansur

Abstract

Herein, we sought to determine the sensitivity to change in cognitive function, as measured by the THINC-it tool, in a sample of adults with major depressive disorder (MDD) receiving standardized antidepressant therapy. Adults meeting the DSM-5 criteria for MDD with at least moderate depressive symptom severity [i.e., Montgomery Åsberg Depression Rating Scale (MADRS) total score ≥ 20] were treated with open-label vortioxetine (10-20 mg/day, flexibly-dosed) for 8 weeks. The previously validated THINC-it tool was the primary dependent measure. The THINC-it tool was validated against the paper and pencil version of the Digit Symbol Substitution Test (DSST) and the Trails Making Test B (TMTB). After 8 weeks of treatment, adults with MDD exhibited improvement in cognitive function relative to healthy controls (e.g., processing speed) (p = 0.031). A subdomain measure of working memory (i.e., symbol check; SC) exhibited significant improvement at Weeks 2 and 8 in latency (p = 0.032), SC accuracy (p = 0.046), and objective z-score (p = 0.001) independent of depressive symptoms. A linear regression analysis determined that the THINC-it tool measures of processing speed, as well as executive function were significantly associated with ch...Continue Reading

Associated Clinical Trials

References

Jun 5, 2016·The Lancet. Psychiatry·John E HarrisonRoger S McIntyre
May 13, 2017·Pharmacological Reports : PR·Magdalena Sowa-KućmaMagdalena Koperny
Dec 20, 2018·Frontiers in Psychiatry·Hannah ZuckermanRoger S McIntyre
Jan 16, 2019·CNS Spectrums·Roger S McIntyreStephen M Stahl

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Methods Mentioned

BETA
pharmacotherapy

Clinical Trials Mentioned

NCT03053362

Software Mentioned

THINC
it

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