The thioredoxin-1 and glutathione/glutaredoxin-1 systems redundantly fuel murine B-cell development and responses

European Journal of Immunology
Jonathan MuriManfred Kopf

Abstract

Antioxidant systems maintain cellular redox homeostasis. The thioredoxin-1 (Trx1) and the glutathione (GSH)/glutaredoxin-1 (Grx1) systems are key players in preserving cytosolic redox balance. In fact, T lymphocytes critically rely on reducing equivalents from the Trx1 system for DNA biosynthesis during metabolic reprogramming upon activation. We here show that the Trx1 system is also indispensable for development and functionality of marginal zone (MZ) B cells and B1 cells in mice. In contrast, development of conventional B cells, follicular B-cell homeostasis, germinal center reactions, and antibody responses are redundantly sustained by both antioxidant pathways. Proliferating B2 cells lacking Txnrd1 have increased glutathione (GSH) levels and upregulated cytosolic Grx1, which is barely detectable in expanding thymocytes. These results suggest that the redox capacity driving proliferation is more robust and flexible in B cells than in T cells, which may have profound implications for the therapy of B and T-cell neoplasms.

References

May 1, 1991·The Journal of Experimental Medicine·R R HardyK Hayakawa
Jan 1, 1985·Annual Review of Biochemistry·A Holmgren
Mar 15, 1997·Nucleic Acids Research·R C RickertK Rajewsky
Jan 1, 1997·Annual Review of Immunology·M F Bachmann, R M Zinkernagel
Jan 27, 2000·Cell·D Hanahan, R A Weinberg
Sep 30, 2000·European Journal of Biochemistry·E S Arnér, A Holmgren
Feb 24, 2001·Antioxidants & Redox Signaling·A Holmgren
Mar 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tazio StorniMartin F Bachmann
Mar 15, 2002·The Journal of Biological Chemistry·Aristi PotamitouAlexios Vlamis-Gardikas
Apr 23, 2002·Nature Immunology·Kenji TanigakiTasuku Honjo
Jan 30, 2004·The Journal of Toxicological Sciences·Toshiyuki WatanabeSunao Manabe
Feb 17, 2005·Molecular and Cellular Biology·Cemile JakupogluMarcus Conrad
Oct 22, 2005·Nature Reviews. Immunology·Casey J FoxCraig B Thompson
Oct 24, 2006·Seminars in Cancer Biology·Sabine Urig, Katja Becker
Nov 10, 2006·Seminars in Cancer Biology·Elias S J Arnér, Arne Holmgren
Nov 23, 2006·Antioxidants & Redox Signaling·Christopher Horst Lillig, Arne Holmgren
Feb 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andrea JegerlehnerMartin F Bachmann
Feb 20, 2007·Microbes and Infection·Dominique GattoMartin F Bachmann
Feb 27, 2007·Free Radical Biology & Medicine·Christine MarzanoMaria Pia Rigobello
Mar 14, 2007·Free Radical Biology & Medicine·Sylvie CamierMarie-Claude Marsolier-Kergoat
Jul 6, 2007·Current Opinion in Pharmacology·Garth Powis, D Lynn Kirkpatrick
Aug 19, 2007·Free Radical Biology & Medicine·Alla A BondarevaEdward E Schmidt
Oct 4, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Fay J DufortThomas C Chiles
Oct 28, 2008·Biological Chemistry·Gary T Jennings, Martin F Bachmann
Nov 4, 2008·Molecular Nutrition & Food Research·Kathryn F Tonissen, Giovanna Di Trapani
Oct 27, 2009·Nature Reviews. Immunology·Shiv Pillai, Annaiah Cariappa
Sep 21, 2010·Free Radical Biology & Medicine·Arne Holmgren, Rajib Sengupta
Dec 27, 2011·Free Radical Biology & Medicine·Justin R PriggeEdward E Schmidt
Jan 11, 2012·Antioxidants & Redox Signaling·Milena BertolottiAnna Rubartelli
Mar 21, 2012·IUBMB Life·Robert C Stanton
Aug 15, 2012·Immunological Reviews·Gerritje J W van der Windt, Erika L Pearce
Sep 20, 2012·Nature Immunology·Ruoning Wang, Douglas R Green
Sep 22, 2012·Biochimica Et Biophysica Acta·Shelly C Lu
Apr 23, 2013·Immunity·Erika L Pearce, Edward J Pearce
Jan 1, 2010·Cancers·Therese Christina Karlenius, Kathryn Fay Tonissen

❮ Previous
Next ❯

Citations

Sep 10, 2020·European Journal of Immunology·Jonathan MuriManfred Kopf
Jan 19, 2021·Free Radical Biology & Medicine·Fang-Yi SuWen-Hwa Lee
Dec 20, 2020·Nature Reviews. Immunology·Jonathan Muri, Manfred Kopf
Jan 26, 2022·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jonathan MuriManfred Kopf

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.