The Thomsen-Friedenreich antigen-binding lectin jacalin interacts with desmoglein-1 and abrogates the pathogenicity of pemphigus foliaceus autoantibodies in vivo.

The Journal of Investigative Dermatology
Ning LiL A Diaz

Abstract

Pemphigus foliaceus (PF) is an autoimmune skin blistering disease mediated by pathogenic autoantibodies against the desmosomal core glycoprotein desmoglein-1 (Dsg1). This study demonstrated that the O-glycan-specific plant lectin jacalin binds Dsg1 and inhibits the interaction of Dsg1/PF IgG. N-glycosylation is not involved in the interaction of Dsg1/jacalin or Dsg1/PF IgG. Subcutaneous injection of jacalin into neonatal mice drastically reduced PF IgG deposition at the epidermal cell surface and blocked PF IgG-induced skin blisters, both clinically and histologically. Interestingly, another plant lectin, peanut agglutinin, which shares the same carbohydrate specificity toward the O-linked carbohydrate structure known as Thomsen-Friedenreich antigen (TF antigen, Galβ1-3GalNAcα-O-Ser/Thr), also bound Dsg1 and blocked the skin blistering. In contrast, the plant lectin vicia villosa-B4 (VVL-B4), which shares the carbohydrate specificity toward the O-linked monosaccharide known as Thomsen-nouveau antigen (GalNAc-α1-O-Ser/Thr), did not bind Dsg1 and did not show a protective effect against the disease induced by the autoantibodies. Collectively, these results suggest that the binding of jacalin to O-linked TF carbohydrate motifs on ...Continue Reading

References

Jun 1, 1989·The New England Journal of Medicine·B RockL A Diaz
Jan 1, 1968·Proceedings of the Society for Experimental Biology and Medicine·E H BeutnerO G Bier
Nov 1, 1984·The Journal of Experimental Medicine·L KouluJ R Stanley
Jun 15, 1984·Science·G F Springer
May 20, 1982·The New England Journal of Medicine·G J AnhaltL A Diaz
Nov 5, 1997·Clinical Immunology and Immunopathology·A EspañaZ Liu
May 8, 1999·The Journal of Investigative Dermatology·X DingZ Liu
Apr 27, 2001·Journal of Dermatological Science·Y FuteiT Nishikawa
May 2, 2002·The Journal of Investigative Dermatology·Luis A ArteagaUNKNOWN Cooperative Group on Fogo Selvagem Research
Feb 12, 2004·The Journal of Investigative Dermatology. Symposium Proceedings·Valeria AokiUNKNOWN Cooperative Group for Fogo Selvagem Research
Mar 1, 2005·Journal of Molecular Biology·A Arockia JeyaprakashM Vijayan
Nov 15, 2005·The Journal of Clinical Investigation·Ning LiZhi Liu
Nov 15, 2006·Autoimmunity·David S Rubenstein, Luis A Diaz
Nov 30, 2006·Neoplasia : an International Journal for Oncology Research·Jamie HeimburgKate Rittenhouse-Olson
Jun 19, 2007·Journal of Dermatological Science·Preety SharmaAimee S Payne
Aug 2, 2007·Expert Opinion on Biological Therapy·Kate Rittenhouse-Olson
Dec 21, 2007·Clinical Reviews in Allergy & Immunology·Yasuo Kitajima, Yumi Aoyama
Apr 4, 2008·Histochemistry and Cell Biology·Jens Waschke

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Citations

Mar 25, 2014·Autoimmunity Reviews·Radjiv GoulabchandPhilippe Guilpain
Nov 19, 2005·Veterinary Immunology and Immunopathology·Thierry OlivryGregg A Dean
Oct 22, 2013·La Revue de médecine interne·R GoulabchandP Guilpain

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