The three-dimensional organization of the genome in cellular senescence and age-associated diseases

Seminars in Cell & Developmental Biology
Shane A EvansNicola Neretti

Abstract

Recent advances in genomics and imaging technologies have increased our ability to interrogate the 3D conformation of chromosomes and to better understand principles of organization and dynamics, as well as how their alteration can lead to disease. In this review we describe how these technologies have shed new light into the role of the 3D organization of the genome in defining cellular states in aging and age-associated diseases. We compare the genomic organization in cellular senescence and cancer, discuss the role of the lamina in maintaining the structural and functional integrity of the genome, and we highlight the recent findings on how this organization breaks down in disease states.

Citations

May 16, 2019·ELife·Cori K Cahoon, Diana E Libuda
Sep 18, 2020·The Journal of Biological Chemistry·Peter O BayguinovJames A J Fitzpatrick
May 14, 2021·Developmental Cell·Erin Aboelnour, Boyan Bonev
May 18, 2021·Computational and Structural Biotechnology Journal·Haiyan GongXiaotong Zhang

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