PMID: 8583289Nov 1, 1995Paper

The three-week-old piglet as a model animal for studying protein digestion in human infants

Journal of Pediatric Gastroenterology and Nutrition
A J Darragh, Paul J Moughan

Abstract

The piglet was evaluated as a model animal for studying the digestion of high-quality proteins in human infants. Three-week-old male piglets (n = 6) and 3-month-old male human infants (n = 6) were fed a bovine-milk-based formula over a 17-day experimental period comprising 7 days' adaptation followed by a 10-day fecal collection period. The piglets and infants were given 345-g liquid formula/kg body weight/day and 170-g liquid formula/kg body weight/day, respectively, which equated to similar dry matter intakes per unit stomach volume (0.923 g dry matter/cm3/day). Both the piglets and infants were individually bottle-fed the reconstituted milk formula (12.2% dry matter) at similar meal frequencies. Small but statistically significant differences (p < 0.01) were found for the apparent fecal digestibility (mean +/- overall SE) of dietary dry matter (98.8 versus 97.4% +/- 0.13%), organic matter (99.0 versus 97.7% +/- 0.12%), and total nitrogen (97.5 versus 94.5% +/- 0.36%) between the piglets and infants. The fecal digestibilities for most of the amino acids were not significantly different (p > 0.05) between the species. The digestion of protein appeared to be similar in the two species. The study provides support for using the p...Continue Reading

Citations

Mar 2, 2012·The British Journal of Nutrition·Karima BouzerzourDidier Dupont
Oct 31, 2012·The British Journal of Nutrition·Amelie Deglaire, Paul J Moughan
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