The three-year effect of a single zoledronate infusion on bone mineral density and bone turnover markers following denosumab discontinuation in women with postmenopausal osteoporosis.

Bone
Polyzois MakrasAthanasios D Anastasilakis

Abstract

In women with postmenopausal osteoporosis denosumab discontinuation is associated with rapid bone loss that could be potentially prevented by a single zoledronate infusion for two years. The longer-term effects, however, of zoledronate treatment are unknown. We aimed to study the effect of a single zoledronate infusion during the third year following denosumab discontinuation, in initially treatment-naive postmenopausal women who became osteopenic after 2.4 ± 0.2 years of denosumab therapy. We report the 1-year follow-up results of a single arm observational extension of a previously reported 2-year multicenter prospective randomized clinical trial. The primary endpoint of this extension was the change in lumbar spine bone mineral density (LS-BMD); secondary endpoints were changes in femoral neck (FN)-BMD and markers of bone turnover (BTM) during the 3rd year from the zoledronate infusion. Changes are presented as mean and SEM. LS-BMD did not change significantly at year 3 compared to year 2 (-1.35 ± 1.1%, p = 1.00) and compared to baseline (-1.96 ± 1.44%, p = 1.00). FN-BMD values did not change while serum P1NP values decreased and CTX values remained unchanged during the third-year of the follow-up. In 4 of the 23 studied wom...Continue Reading

Citations

Oct 27, 2020·The Journal of Clinical Endocrinology and Metabolism·Elena TsourdiBente Langdahl
Dec 30, 2020·Expert Opinion on Drug Safety·Polyzois Makras, Athanasios D Anastasilakis
Jan 3, 2021·Calcified Tissue International·Athanasios D AnastasilakisPolyzois Makras
Feb 6, 2021·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Athanasios D AnastasilakisSymeon Tournis
Jan 8, 2021·Journal of Clinical Medicine·Athanasios D AnastasilakisAndrea Palermo
Jan 29, 2021·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Sabashini K RamchandBenjamin Z Leder
Apr 5, 2021·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Anne Sophie SøllingBente Langdahl
Jun 10, 2021·Therapeutic Advances in Endocrinology and Metabolism·Jane A NobleRachel K Crowley
Jul 27, 2021·Expert Review of Endocrinology & Metabolism·Hotaka IshizuNorimasa Iwasaki
May 13, 2021·The Journal of Clinical Endocrinology and Metabolism·Polyzois MakrasAthanasios D Anastasilakis
Sep 16, 2021·Clinical and Experimental Pharmacology & Physiology·Wang WangQibin Lu
Nov 12, 2021·Advances in Therapy·David L KendlerSerge Ferrari

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