The three-year incidence of major hemorrhage among older adults initiating chronic dialysis

Canadian Journal of Kidney Health and Disease
Manish M SoodAmit X Garg

Abstract

For those who initiate chronic dialysis, knowing what proportion will experience 3-year outcomes of hemorrhage with hospitalization informs patient prognosis, disease impact, and the planning of trials and programs to prevent events. We examined the incidence of hemorrhage and related gastrointestinal endoscopic procedures in incident older dialysis patients and stratified patients by age, era, dialysis modality and whether recently prescribed anti-thrombotic medication. Retrospective cohort study. Ontario, Canada from 1998 to 2008 (n = 11,173). All older patients (>65 years) who initiated chronic dialysis. Hospitalization with hemorrhage and its subtypes (upper and lower gastrointestinal, intra-cerebral, subarachnoid) and related-gastrointestinal procedures. Three-year outcomes of hospitalization with hemorrhage were expressed as cumulative incidence and incidence rate (number of events per 1,000 patient years). Results were stratified by patient age (66 to 74, 75 to 84, ≥ 85), era (1998 to 2001, 2002 to 2005, 2006 to 2008) and dialysis modality. Among those with hemorrhage, we examined prescriptions for anti-thrombotic medications (warfarin, clopidogrel) in the preceding 120 days. The 3-year cumulative incidence of hemorrhage...Continue Reading

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Citations

Jan 30, 2016·Journal of the American Society of Nephrology : JASN·Amber O MolnarManish M Sood
Mar 9, 2017·Canadian Journal of Kidney Health and Disease·Amber O MolnarGreg Knoll
Mar 24, 2018·Current Opinion in Nephrology and Hypertension·Justin Ashley, Manish M Sood
Dec 6, 2014·Seminars in Dialysis·Bassem Y TaniosDeborah L Zimmerman
Nov 1, 2016·Clinical Journal of the American Society of Nephrology : CJASN·Vaibhav Keskar, Manish M Sood
Aug 16, 2017·Kidney International·Vaibhav KeskarManish M Sood

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