The threshold length for fiber-induced acute pleural inflammation: shedding light on the early events in asbestos-induced mesothelioma.

Toxicological Sciences : an Official Journal of the Society of Toxicology
Anja SchinwaldKen Donaldson

Abstract

Suspicion has been raised that high aspect ratio nanoparticles or nanofibers might possess asbestos-like pathogenicity. The pleural space is a specific target for disease in individuals exposed to asbestos and by implication of nanofibers. Pleural effects of fibers depends on fiber length, but the key threshold length beyond which adverse effects occur has never been identified till now because all asbestos and vitreous fiber samples are heterogeneously distributed in their length. Nanotechnology advantageously allows for highly defined length distribution of synthetically engineered fibers that enable for in-depth investigation of this threshold length. We utilized the ability to prepare silver nanofibers of five defined length classes to demonstrate a threshold fiber length for acute pleural inflammation. Nickel nanofibers and carbon nanotubes were then used to strengthen the relationship between fiber length and pleural inflammation. A method of intrapleural injection of nanofibers in female C57Bl/6 strain mice was used to deliver the fiber dose, and we then assessed the acute pleural inflammatory response. Chest wall sections were examined by light and scanning electron microscopy to identify areas of lesion; furthermore, c...Continue Reading

References

Feb 1, 1992·American Journal of Respiratory Cell and Molecular Biology·K C StoneJ D Crapo
Apr 1, 1989·British Journal of Industrial Medicine·K DonaldsonJ M Davis
Jun 1, 1993·The Clinical Investigator·B Fischer, K Morgenroth
Mar 1, 1993·Archives of Histology and Cytology·M OyaY Uchida
Jan 1, 1996·World Journal of Urology·D B Rukstalis
Jul 5, 2002·Respiration; International Review of Thoracic Diseases·K-M MüllerK Konstantinidis
Sep 10, 2002·The American Journal of Surgical Pathology·Krassimir MitchevPaul De Vuyst
Feb 4, 2003·Annals of the New York Academy of Sciences·Yasunosuke Suzuki, Steven R Yuen
Aug 21, 2003·American Journal of Industrial Medicine·Ronald F DodsonJeffrey L Levin
Mar 27, 2004·Physiological Reviews·Stephen J Lai-Fook
Nov 27, 2004·Chemistry : a European Journal·Benjamin WileyYounan Xia
Jan 26, 2008·Environmental Health : a Global Access Science Source·G MiserocchiGerolamo Chiappino
Nov 7, 2009·Nature Nanotechnology·Jessica P Ryman-RasmussenJames C Bonner
Jan 14, 2010·American Journal of Respiratory Cell and Molecular Biology·Nicholas H HeintzBrooke T Mossman
Oct 6, 2010·Particle and Fibre Toxicology·Robert R MercerDale W Porter
Oct 12, 2010·Nanotoxicology·Ken DonaldsonRoel P F Schins
Jan 27, 2011·Particle and Fibre Toxicology·Larissa V StebounovaPeter S Thorne
May 3, 2011·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Brooke T MossmanJames C Bonner
Jul 26, 2011·Particle and Fibre Toxicology·Robert R MercerDale W Porter
Nov 16, 2011·Bulletin of the World Health Organization·Vanya DelgermaaTom Sorahan

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Citations

Sep 26, 2012·Accounts of Chemical Research·Ken DonaldsonCraig Poland
Jul 31, 2013·Particle and Fibre Toxicology·Robert R MercerDale W Porter
Aug 10, 2013·Particle and Fibre Toxicology·Robert R MercerDale W Porter
Aug 10, 2013·Advanced Drug Delivery Reviews·Sophie LanoneJorge Boczkowski
Aug 1, 2013·Advanced Drug Delivery Reviews·Ken DonaldsonAnja Schinwald
Sep 13, 2014·Archives of Toxicology·Peter MøllerSteffen Loft
Feb 2, 2016·International Journal of Molecular Sciences·Yasuo MorimotoKazuhiro Yamamoto
Dec 24, 2014·International Journal of Molecular Sciences·Ioannis G TheodorouAlexandra E Porter
Jun 19, 2013·Current Opinion in Biotechnology·Ken Donaldson, Craig A Poland
Jun 27, 2015·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·David Y Lai
Nov 21, 2014·Particle and Fibre Toxicology·Susanne RittinghausenDirk Schaudien
Dec 17, 2014·Particle and Fibre Toxicology·Sybille van den BruleJérôme Rose
Oct 9, 2014·Particle and Fibre Toxicology·Rona M SilvaKent E Pinkerton
Mar 27, 2015·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Enrico BergamaschiSyed A M Tofail
Apr 15, 2014·Particle and Fibre Toxicology·Hedwig M BraakhuisFlemming R Cassee
May 15, 2015·Particle and Fibre Toxicology·Jiyoung JeongWan-Seob Cho
Apr 29, 2014·Critical Reviews in Toxicology·Paolo BoffettaJack S Mandel
Aug 9, 2013·Nanotoxicology·Anja SchinwaldColin J Campbell
Mar 22, 2014·The Journal of Toxicological Sciences·Tomoko FujitaniDai Nakae
Dec 30, 2014·Biomaterials·Lina GällentoftCecilia Eriksson Linsmeier
Jul 23, 2016·Canadian Respiratory Journal : Journal of the Canadian Thoracic Society·Robert M Ross
May 25, 2016·International Journal of Occupational and Environmental Health·David Egilman, Triet Tran
Jul 22, 2014·Environmental Health : a Global Access Science Source·Guillaume BoulangerMarie-Claude Jaurand
Oct 4, 2016·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Paul FowlerRoberta Bradford
Oct 30, 2016·Biochimica Et Biophysica Acta. General Subjects·Trudy PadmoreJulie A Champion
Nov 7, 2016·Particle and Fibre Toxicology·Jo Anne Shatkin, Günter Oberdörster
Aug 5, 2017·Journal of Biological Dynamics·Alisa DeStefanoDorothy I Wallace
Feb 24, 2018·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Antonio PietroiustiKai Savolainen
Oct 12, 2017·Environmental Health Perspectives·Vicki StoneFlemming R Cassee
Mar 16, 2019·Critical Reviews in Toxicology·Craig A Poland, Rodger Duffin

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