The Thrombospondin1-TGF-β Pathway and Glaucoma

Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics
Joanne E Murphy-Ullrich, J Crawford Downs

Abstract

Glaucoma is characterized by abnormal remodeling of the extracellular matrix (ECM) in the trabecular meshwork and in the connective tissue beams of the lamina cribrosa (LC) at the optic nerve head (ONH), which is associated with axonal damage. Mechanical strain can stimulate ECM remodeling and increased expression of matricellular proteins. Thrombospondins 1 and 2 are induced by cyclic mechanical strain in the eye in both the trabecular meshwork and in the LC region of the ONH. TGF-betas 1 and 2 are increased in glaucoma and play a role in the pathologic remodeling of the ECM in the eye in glaucoma. In this study, we address the role of thrombospondin1 as a regulator of latent TGF-beta activation and discuss the potential therapeutic use of antagonists of the thrombospondin1-TGF-beta pathway for treatment of glaucoma.

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Citations

Nov 30, 2016·Current Opinion in Ophthalmology·J Crawford Downs, Christopher A Girkin
Jan 21, 2021·Toxicologic Pathology·Meg Ferrell RamosSharmila Masli
Apr 20, 2020·The Journal of Investigative Dermatology·Bettina BerberichJörn Dengjel
Apr 4, 2021·Cells·Andrew E PouwElliott H Sohn

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Methods Mentioned

BETA
antisense oligonucleotides

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