PMID: 8976193Dec 1, 1996Paper

The thymus contains a high frequency of cells that prevent autoimmune diabetes on transfer into prediabetic recipients

The Journal of Experimental Medicine
A SaoudiD Mason

Abstract

Rats of the PVG.RT1u strain develop autoimmune diabetes when thymectomized at 6 wk of age and are rendered relatively lymphopenic by a cumulative dose of 1,000 rads 137Cs gamma-irradiation given in four split doses. Previous studies have shown that the disease is prevented by the intravenous injection of 5 x 10(6) CD4+ CD45RC-TCR alpha beta+ RT6+ peripheral T cells from normal syngeneic donors. These cells have a memory phenotype and are presumably primed to some extrathymic antigen. However, we now report that the CD4+ CD8- population of mature thymocytes is a very potent source of cells, with the capacity to prevent diabetes in our lymphopenic animals. As few as 6 x 10(5) of these cells protect approximately 50% of recipients and the level of protection increases with cell dose. It appears that one characteristic of the intrathymic selection of the T cell repertoire is the generation of cells that regulate the autoimmune potential of peripheral T cells that have been neither clonally deleted intrathymically nor rendered irreversibly anergic in the periphery.

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Citations

Nov 26, 1999·Life Sciences·V Kumar, E Sercarz
Feb 1, 2000·Immunology Today·B Seddon, D Mason
Mar 11, 1998·Current Opinion in Immunology·K S TungC Teuscher
Jan 23, 1999·Current Opinion in Immunology·D Mason, F Powrie
Aug 26, 2006·Nature Clinical Practice. Endocrinology & Metabolism·Simona Cernea, Kevan C Herold
Aug 30, 2001·Nature Immunology·K J Maloy, F Powrie
Jan 3, 2007·Prostate Cancer and Prostatic Diseases·E V VykhovanetsS Gupta
Jul 6, 2001·Scandinavian Journal of Immunology·J F Bach
Mar 2, 1999·The Journal of Experimental Medicine·B Seddon, D Mason
Jun 8, 2001·The Journal of Experimental Medicine·E M Shevach
Dec 6, 2003·The Journal of Experimental Medicine·Ana C Anderson, Vijay K Kuchroo
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Oct 27, 2004·Journal of Autoimmunity·Margot ZöllerRolf Hoffmann

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