The thymus-dependent nature of the murine antibody response to a monoclonal anti-idiotypic antibody to the Neisseria meningitidis serogroup C capsular polysaccharide

Microbial Pathogenesis
M A WesterinkM A Apicella

Abstract

Idiotype vaccines are proteins which may offer an alternative strategy for the conversion of a thymus-independent antigen into a thymus-dependent immunogen. To examine this question, we have studied the nature of the immune response to a monoclonal anti-idiotypic antibody, designated 6F9, which acts as a surrogate of Neisseria meningitidis serogroup C capsular polysaccharide, and compared this response to the nominal antigen, the meningococcal C-polysaccharide (MCP). BALB/c mice immunized with an optimal dose (100 micrograms) of 6F9 generate a specific anti-MCP IgG response which is maximal after 4 weeks. Secondary immunization with 6F9 results in a three- to five-fold increase in the specific IgG response. Mice given an optimal immunizing dose of MCP (5 micrograms) failed to generate an anti-MCP IgG response. No secondary response is detectable in mice immunized with MCP. Animals immunized with 6F9 and subsequently challenged with live meningococci group C show a significant anti-MCP IgG response. BALB/c nu/nu mice fail to generate an anti-MCP IgG antibody response to 6F9, while the nu/+ controls generate an anti-MCP IgG antibody titer 100 times that of the MCP-immunized mice. Neonatal mice that failed to respond to MCP develo...Continue Reading

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Citations

Sep 29, 2001·Journal of Microbiological Methods·G B Lesinski, M A Westerink
Apr 13, 1999·Infectious Disease Clinics of North America·P S Hefty, R C Kennedy
Apr 25, 1995·Proceedings of the National Academy of Sciences of the United States of America·M A WesterinkT Kieber-Emmons
Aug 15, 1994·Annals of the New York Academy of Sciences·M A WesterinkM A Apicella
Mar 24, 2006·FEMS Immunology and Medical Microbiology·Antonio E PérezGerardo Guillén

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