Abstract
The existence of a dense structural and hormonal innervation of the immune system provides the first link in the interaction among the central nervous system, the endocrine system and the immune system. Our recent localization of a specific beta(2)-adrenergic receptor population in the medulla of the rat thymus gland, undergoing important changes in density and distribution during ontogenic development, coupled with a marked sexual dimorphism during maturation, prompted us to study changes in distribution of the thymic beta-adrenergic receptor under experimental conditions accompanied by marked fluctuations of the sex steroid hormonal milieu, using in vitro autoradiography. Moreover, such changes were correlated with alterations in thymocyte proliferative response and thymus histology. Slidemounted cryostat sections were incubated with iodocyanopindolol ([(125)I]CYP), a specific ligand for beta-adrenergic receptors. Labeling was detected by autoradiography, by exposing the sections to Ultrofilm (LKB). The vast majority of receptors localized in the medullar compartment of the thymus are of the beta(2)-subtype, with no qualitative changes in the predominant beta(2)-adrenergic population under the different conditions studied. Du...Continue Reading
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