PMID: 19912750Aug 1, 1990Paper

The thymus gland as a major target for the central nervous system and the neuroendocrine system: Neuroendocrine modulation of thymic beta(2)-Adrenergic receptor distribution as revealed by in vitro autoradiography

Molecular and Cellular Neurosciences
B MarchettiG Pelletier

Abstract

The existence of a dense structural and hormonal innervation of the immune system provides the first link in the interaction among the central nervous system, the endocrine system and the immune system. Our recent localization of a specific beta(2)-adrenergic receptor population in the medulla of the rat thymus gland, undergoing important changes in density and distribution during ontogenic development, coupled with a marked sexual dimorphism during maturation, prompted us to study changes in distribution of the thymic beta-adrenergic receptor under experimental conditions accompanied by marked fluctuations of the sex steroid hormonal milieu, using in vitro autoradiography. Moreover, such changes were correlated with alterations in thymocyte proliferative response and thymus histology. Slidemounted cryostat sections were incubated with iodocyanopindolol ([(125)I]CYP), a specific ligand for beta-adrenergic receptors. Labeling was detected by autoradiography, by exposing the sections to Ultrofilm (LKB). The vast majority of receptors localized in the medullar compartment of the thymus are of the beta(2)-subtype, with no qualitative changes in the predominant beta(2)-adrenergic population under the different conditions studied. Du...Continue Reading

References

Jan 1, 1989·Hormone Research·V GeenenP Franchimont
Dec 1, 1985·Naunyn-Schmiedeberg's Archives of Pharmacology·E SchlickerK Hillenbrand
Jan 1, 1970·Acta Endocrinologica. Supplementum·D Rodbard, J E Lewald
Jul 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·H M JohnsonJ E Blalock

❮ Previous
Next ❯

Citations

Mar 1, 1997·Mechanisms of Ageing and Development·K S MaddenD L Felten
May 23, 2001·International Immunopharmacology·G LeposavićB Vidić-Danković
Nov 4, 2008·Autonomic Neuroscience : Basic & Clinical·Gordana LeposavićDusko Kosec
Sep 29, 2011·Neuroimmunomodulation·Eduardo RoggeroAdriana del Rey
Feb 15, 2018·Frontiers in Endocrinology·Gordana Momčilo Leposavić, Ivan M Pilipović
Jun 18, 1998·Annals of the New York Academy of Sciences·B MarchettiM C Morale

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.