PMID: 11327202May 1, 2001Paper

The thymus of the hairless rhino-j (hr/rh-j) mice

Journal of Anatomy
I San JoseJ A Vega

Abstract

The hairless (hr) gene is expressed in a large number of tissues, primarily the skin, and a mutation in the hr gene is responsible for the typical cutaneous phenotype of hairless mice. Mutant hr mouse strains show immune defects involving especially T cells and macrophages, as well as an age-related immunodeficiency and an accelerated atrophy of the thymus. These data suggest that the hr mutation causes a defect of this organ, although hr transcripts have not been detected in fetal or adult mice thymus. The present study analyses the thymus of young (3 mo) and adult (9 mo) homozygous hr-rh-j mice (a strain of hairless mice) by means of structural techniques and immunohistochemistry to selectively identify thymic epithelial cells, dendritic cells, and macrophages. There were structural alterations in the thymus of both young and adult rh-rh-j mice, which were more severe in older animals. These alterations consisted of relative cortical atrophy, enlargement of blood vessels, proliferation of perivascular connective tissue, and the appearance of cysts. hr-rh-j mice also showed a decrease in the number of epithelial and dendritic cells, and macrophages. Taken together, present results strongly suggest degeneration and accelerated ...Continue Reading

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Citations

Mar 11, 2004·Experimental and Molecular Pathology·Maud-Virginie BrancazStefan Nonchev
Jan 24, 2006·Infection and Immunity·Yehoshua GozesStephen H Leppla
May 12, 2006·Médecine sciences : M/S·Stefan NonchevRabah Iratni
Jan 19, 2005·The Journal of Investigative Dermatology·Annika VogtErvin H Epstein
Nov 25, 2003·Microscopy Research and Technique·Lourdes Domínguez-Gerpe, Manuel Rey-Méndez
Nov 25, 2003·Microscopy Research and Technique·Alberto VarasAngeles Vicente
Jun 30, 2016·Journal of Cellular Biochemistry·Lemlem BrookJui-Cheng Hsieh
Jul 20, 2016·Aging·Ilja L Kruglikov, Philipp E Scherer
Mar 14, 2021·The Journal of Allergy and Clinical Immunology·Satoshi NakamizoKenji Kabashima
Jul 28, 2007·The Journal of Investigative Dermatology·Maud-Virginie Brancaz-BouvierStefan Nonchev

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