The thyroglobulin gene as the first thyroid-specific susceptibility gene for autoimmune thyroid disease

Trends in Molecular Medicine
Yaron Tomer, D A Greenberg

Abstract

Recent linkage and association studies provide evidence for thyroglobulin (Tg) being an autoimmune thyroid disease (AITD) susceptibility gene. The Tg locus has been reported to be linked with AITD in two independent studies, and further analysis demonstrated that markers within the Tg gene were associated with AITD. Furthermore, missense single-nucleotide polymorphisms (SNPs) in the Tg gene were shown to be associated with autoimmune thyroiditis in both mice and humans. If Tg is confirmed as a susceptibility gene for AITD, it could provide a novel therapeutic target.

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Citations

May 2, 2006·Thyroid : Official Journal of the American Thyroid Association·Susan E HodgeYaron Tomer
Jul 8, 2010·Thyroid : Official Journal of the American Thyroid Association·Yaron Tomer
Mar 26, 2011·Briefings in Functional Genomics·Matthew J Simmonds, Stephen C L Gough
Mar 15, 2005·Journal of Autoimmune Diseases·Dimitry A Chistiakov
Mar 25, 2009·Journal of Autoimmunity·Yaron Tomer, Amanda Huber
Dec 18, 2007·Clinical Endocrinology·Abigail A ZeitlinStephen C L Gough
Jan 8, 2017·Thyroid : Official Journal of the American Thyroid Association·Raja Y ZaghlolAyman A Zayed
Nov 19, 2013·Internal Medicine·Hidefumi InabaTakashi Akamizu

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