PMID: 2493818Mar 15, 1989Paper

The thyroid axis and desipramine treatment in depression

Biological Psychiatry
K T Brady, R F Anton

Abstract

Although there has been much recent investigation of the role of thyroid function in affective illness, few studies have addressed the effects of the tricyclic antidepressants on the pituitary-thyroid axis. In the present study, thyroid functions (TFTs) and thyrotropin-releasing hormone (TRH) stimulation of thyroid-stimulating hormone (TSH) were measured before and after treatment with desipramine (DMI) in 13 men with a diagnosis of major depressive disorder. All subjects had normal TFTs and baseline TSH measured in a drug-free state at the initiation of the study. Both mean free thyroxine index and baseline TSH decreased after DMI treatment. The amount of decrease in baseline TSH correlated with increase in delta TSH. Four subjects had blunted delta TSH (delta TSH less than or equal to 5 microIU/ml); three of these subjects "normalized" with treatment (delta TSH less than or equal to 5 microIU/ml; greater than or equal to 20 microIU/ml). Two subjects had a high delta TSH, and both "normalized" during treatment. The decrease in both free T4 index and TSH suggests a down-regulation of the thyroid axis at the hypothalamic level. "Normalization" of subtle dysregulation of the thyroid axis is suggested as a mechanism of antidepress...Continue Reading

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Citations

Jan 15, 1993·Biological Psychiatry·R C SheltonP T Loosen
Dec 1, 1994·Biological Psychiatry·K T BradyT E Steele
Sep 19, 1996·European Journal of Pharmacology·A YoshidaC Shigemasa
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May 4, 2010·Neuroscience Letters·Stephan RothUlrich Schweizer
Feb 12, 2008·Progress in Neuro-psychopharmacology & Biological Psychiatry·Salih Saygin EkerSelcuk Kirli
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