The Thyroid Hormone Analog DITPA Ameliorates Metabolic Parameters of Male Mice With Mct8 Deficiency

Endocrinology
Alfonso Massimiliano FerraraSamuel Refetoff

Abstract

Mutations in the gene encoding the thyroid hormone (TH) transporter, monocarboxylate transporter 8 (MCT8), cause mental retardation in humans associated with a specific thyroid hormone phenotype manifesting high serum T3 and low T4 and rT3 levels. Moreover, these patients have failure to thrive, and physiological changes compatible with thyrotoxicosis. Recent studies in Mct8-deficient (Mct8KO) mice revealed that the high serum T3 causes increased energy expenditure. The TH analog, diiodothyropropionic acid (DITPA), enters cells independently of Mct8 transport and shows thyromimetic action but with a lower metabolic activity than TH. In this study DITPA was given daily ip to adult Mct8KO mice to determine its effect on thyroid tests in serum and metabolism (total energy expenditure, respiratory exchange rate, and food and water intake). In addition, we measured the expression of TH-responsive genes in the brain, liver, and muscles to assess the thyromimetic effects of DITPA. Administration of 0.3 mg DITPA per 100 g body weight to Mct8KO mice brought serum T3 levels and the metabolic parameters studied to levels observed in untreated Wt animals. Analysis of TH target genes revealed amelioration of the thyrotoxic state in liver, s...Continue Reading

References

Sep 1, 1983·The Journal of Clinical Endocrinology and Metabolism·H IshiiH Imura
Feb 20, 2003·Trends in Endocrinology and Metabolism : TEM·Frédéric Flamant, Jacques Samarut
Jan 1, 1959·Endocrinology·N R STASILLIR I MELTZER
Feb 24, 2007·The Journal of Clinical Investigation·Marija TrajkovicHeike Heuer
Feb 19, 2008·Thyroid : Official Journal of the American Thyroid Association·Warner S Simonides, Cornelis van Hardeveld
Feb 19, 2008·Thyroid : Official Journal of the American Thyroid Association·Maria MorenoFernando Goglia
Aug 4, 2010·The Journal of Clinical Investigation·Caterina Di CosmoSamuel Refetoff
Sep 21, 2012·The Journal of Clinical Endocrinology and Metabolism·Charles F VergeSamuel Refetoff
May 23, 2013·Endocrinology·Alfonso Massimiliano FerraraSamuel Refetoff
Jul 23, 2014·Endocrinology·Alfonso Massimiliano FerraraSamuel Refetoff

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Citations

Apr 5, 2016·Thyroid : Official Journal of the American Thyroid Association·W Edward VisserTheo J Visser
Jan 26, 2017·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Hongyan Dong, Michael G Wade
May 31, 2018·Thyroid : Official Journal of the American Thyroid Association·Soledad Bárez-LópezAna Guadaño-Ferraz
Feb 6, 2019·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·Alessandra Quintino-MoroArlete Fernandes
Nov 23, 2019·Endocrine Reviews·Stefan GroenewegW Edward Visser
May 16, 2020·Frontiers in Neuroscience·Carmen Grijota-MartínezAna Guadaño-Ferraz
Jul 31, 2019·Endocrine·Rosalba SeneseAntonia Lanni
Jun 2, 2020·Frontiers in Endocrinology·Pieter VancampSylvie Remaud
Jul 17, 2021·Toxicological Sciences : an Official Journal of the Society of Toxicology·M E GilbertJ L Ford
Aug 31, 2021·Toxicological Sciences : an Official Journal of the Society of Toxicology·Mary E GilbertJermaine L Ford

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