The thyrotropin (TSH) profile in isolated gonadotropin deficiency: a model to evaluate the effect of sex steroids on TSH secretion

The Journal of Clinical Endocrinology and Metabolism
I M SpitzS Trestian

Abstract

This study evaluated the effect of estrogens and androgens on TSH secretion in hypogonadal male and female patients with isolated gonadotropin deficiency (IGD). The IGD subjects were clinically euthyroid and had normal circulating levels of thyroid hormones and T4-binding globulin (TBG). The patients were challenged with TRH (200 micrograms) in the untreated state, during treatment, and 1 month after cessation of hormonal replacement therapy. For the study, five females were treated with ethinyl estradiol (0.05 mg twice daily) for 21 days; after stopping for 7 days, the treatment schedule was repeated for another two cycles. The remaining female was given a similar regimen with conjugated estrogens (0.625 mg daily). Five males were treated with hCG (5000 IU twice weekly) for 3 months; two were treated with hCG and Pergonal. The female patients had significantly decreased basal TSH levels as well as impaired TSH responses to TRH. After 3 months of ethinyl estradiol treatment, there was a rise in TBG, total serum T4 and T3 levels and a decrease in T3 resin uptake; the free T4 index was unchanged. During estrogen administration, there was no change in basal TSH, but there was an increase in the peak TSH response to TRH, which beca...Continue Reading

Citations

Jul 1, 1997·Endocrine Pathology·Lucia Stefaneanu
Jun 21, 2002·Obstetrical & Gynecological Survey·Marcy A Adlersberg, Gerard N Burrow
Sep 1, 1989·Clinical Endocrinology·J YehS S Yen
Sep 4, 2015·Archives of Endocrinology and Metabolism·Ayten OguzKamile Gul
Sep 1, 1988·Acta Psychiatrica Scandinavica·V S WahbyJ W Mason
Aug 8, 2019·Journal of Clinical Pharmacology·Robert KrysiakBogusław Okopień

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