The tick salivary protein Salp15 inhibits the killing of serum-sensitive Borrelia burgdorferi sensu lato isolates.

Infection and Immunity
T J SchuijtA P van Dam

Abstract

Borrelia burgdorferi, the agent of Lyme disease, is transmitted by ticks. During transmission from the tick to the host, spirochetes are delivered with tick saliva, which contains the salivary protein Salp15. Salp15 has been shown to protect spirochetes against B. burgdorferi-specific antibodies. We now show that Salp15 from both Ixodes ricinus and Ixodes scapularis protects serum-sensitive isolates of Borrelia burgdorferi sensu lato against complement-mediated killing. I. ricinus Salp15 showed strong protective effects compared to those of I. scapularis Salp15. Deposition of terminal C5b to C9 (one molecule each of C5b, C6, C7, and C8 and one or more molecules of C9) complement complexes, part of the membrane attack complex, on the surface of B. burgdorferi was inhibited in the presence of Salp15. In the presence of normal human serum, serum-sensitive Borrelia burgdorferi requires protection against complement-mediated killing, which is provided, at least in part, by the binding to the tick salivary protein Salp15.

References

Jan 1, 1980·Advances in Parasitology·K C Binnington, D H Kemp
Apr 1, 1997·Infection and Immunity·A P van DamJ Dankert
Mar 1, 1997·Medical Microbiology and Immunology·S Breitner-RuddockV Brade
Dec 22, 1999·Experimental Parasitology·C H LawrieP A Nuttall
Dec 13, 2000·The Journal of Biological Chemistry·J HellwageS Meri
Nov 8, 2002·Insect Molecular Biology·S NarasimhanE Fikrig
Mar 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mario PausaFrancesco Tedesco
Apr 23, 2004·Infection and Immunity·Ruth R MontgomeryStephen E Malawista
Jul 29, 2005·Nature·Nandhini RamamoorthiErol Fikrig
Jun 15, 2006·The Journal of Biological Chemistry·Michalis KotsyfakisJosé M C Ribeiro
Jun 30, 2006·Thrombosis and Haemostasis·Rômulo A NazarethRobson Q Monteiro
Nov 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Renu GargJuan Anguita
Dec 14, 2006·Journal of Medical Entomology·Katerina Kýcková, Jan Kopecký
Mar 9, 2007·FEMS Immunology and Medical Microbiology·Ignacio J JuncadellaJuan Anguita
Sep 28, 2007·Vector Borne and Zoonotic Diseases·J W R HoviusE Fikrig

❮ Previous
Next ❯

Citations

Jan 23, 2009·Journal of Molecular Evolution·Petra Catalina Schwalie, Jörg Schultz
Apr 9, 2010·Current Opinion in Rheumatology·Bettina Panagiota Iliopoulou, Brigitte T Huber
Apr 1, 2009·Infection and Immunity·Xiuyang GuoRuth R Montgomery
Jan 7, 2014·PloS One·Bryan TroxellX Frank Yang
Jul 5, 2013·PLoS Pathogens·Stephen G PrestonJonathan M Austyn
Feb 24, 2016·Vector Borne and Zoonotic Diseases·Alex WagemakersJoppe W R Hovius
Nov 24, 2011·Ticks and Tick-borne Diseases·Austin L Hughes, Robert Friedman
Mar 19, 2011·Journal of the American Academy of Dermatology·Chinmoy Bhate, Robert A Schwartz
Jul 21, 2011·Ticks and Tick-borne Diseases·N D van BurgelA P van Dam
Oct 12, 2010·The Veterinary Clinics of North America. Small Animal Practice·Inke Krupka, Reinhard K Straubinger
Jan 30, 2015·FEBS Open Bio·Philipp KolbMichael Nassal
Aug 12, 2014·International Journal for Parasitology·Lwiindi MudendaKelly A Brayton
Dec 4, 2015·Ticks and Tick-borne Diseases·Christian MelaunSven Klimpel
Jun 26, 2014·Critical Reviews in Microbiology·Marije OostingLeo A B Joosten
Mar 23, 2015·Insect Biochemistry and Molecular Biology·Yusuke MuraseKazuhko Ohashi
Jul 3, 2010·Trends in Parasitology·T J SchuijtE Fikrig
Jan 10, 2013·Trends in Parasitology·Steven W de TaeyeTim J Schuijt
Feb 15, 2008·PLoS Medicine·Joppe W R HoviusErol Fikrig
Oct 4, 2017·Future Microbiology·Bilal AslamMuhammad Khalid Farooq Salamat
Jul 10, 2019·Infection and Immunity·Yu-Min ChuangErol Fikrig
Oct 18, 2015·Experimental Dermatology·Jürgen Harder
Jan 31, 2020·Frontiers in Immunology·Shiyuan WenFukai Bao
May 8, 2019·Wiener klinische Wochenschrift·Patricia A Nuttall
Jan 1, 2020·Pathogens·Vladimir V BammMelanie K B Wills
Feb 6, 2017·Frontiers in Immunology·Brandee L Stone, Catherine A Brissette
Jul 12, 2020·Nature Reviews. Microbiology·Cheyne KurokawaErol Fikrig
Feb 23, 2020·Frontiers in Cellular and Infection Microbiology·Yi-Pin LinPeter Kraiczy
Jul 12, 2017·Frontiers in Cellular and Infection Microbiology·Ladislav ŠimoSarah I Bonnet
Jan 1, 2021·Immunity, Inflammation and Disease·Tjaša Cerar KišekDaša Stupica
Dec 29, 2020·Parasite Immunology·Jennifer D HelbleLinden T Hu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alternative Complement Pathway

The Alternative Complement Pathway is part of the innate immune system, and activation generates membrane attack complexes that kill pathogenic cells. Discover the latest research on the Alternative Complement Pathway.