The time course of brief and prolonged topical 8% capsaicin-induced desensitization in healthy volunteers evaluated by quantitative sensory testing and vasomotor imaging

Experimental Brain Research
Silvia Lo VecchioL Arendt-Nielsen

Abstract

Topically applied high-concentration capsaicin induces reversible dermo-epidermal denervation and depletion of capsaicin-sensitive nociceptors. This causes desensitization of distinct sensory modalities and is used to treat peripheral neuropathic pain and itch. For high-concentration capsaicin, the selectivity of loss of function and functional recovery rates of various afferent fibers subpopulations are unknown. This study used comprehensive quantitative sensory testing and vasomotor imaging to assess effectiveness, duration and sensory selectivity of high-concentration 8% capsaicin-ablation. Skin areas in 14 healthy volunteers were randomized to treatment with 8% capsaicin/vehicle patches for 1 and 24 h and underwent comprehensive sensory and vasomotor testing at 1, 7 and 21 days postpatch removal. Tests consisted of thermal detection and pain thresholds, tactile and vibration detection thresholds, mechanical pain threshold and mechanical pain sensitivity as well as micro-vascular and itch reactivity to histamine provocations. The 24 h capsaicin drastically inhibited warmth detection (P < 0.001), heat pain (P < 0.001) as well as histamine-induced itch (P < 0.05) and neurogenic flare (P < 0.001), but had no impact on tactile s...Continue Reading

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Citations

Dec 27, 2019·European Journal of Pain : EJP·Marie Hoeger BementThomas Graven-Nielsen
Jun 9, 2020·Frontiers in Pharmacology·Sabien G A van Neerven, André Mouraux
Jan 5, 2021·Frontiers in Physiology·Michael J M FischerArpad Szallasi
Feb 2, 2021·The Journal of Pain : Official Journal of the American Pain Society·Janne D ChristensenLars Arendt-Nielsen
Nov 13, 2020·Pharmacology & Therapeutics·Vipin AroraMan-Kyo Chung
May 9, 2021·Journal of Biotechnology·Ana Emilia Nava-OchoaDaniel Guajardo-Flores
Oct 16, 2021·Lab Animal·Suzan MeijsWinnie Jensen

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Methods Mentioned

BETA
biopsies

Software Mentioned

SPSS
GraphPad Prism
Excel
eVAS

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