Abstract
We studied the effect of changing the duration of isocapnic hyperventilation on the time course of bronchoconstriction in five subjects with asthma. Each subject performed hyperventilation challenges of 4, 8, and 16 min. No significant bronchoconstriction occurred until the hyperventilation was stopped, regardless of its duration. We found increased bronchoconstriction as the duration of hyperventilation increased. The declines in FEV1 (mean +/- SD) from baseline were 13 +/- 10%, 22 +/- 7%, and 29 +/- 12% for 4, 8, and 16 min of hyperventilation, respectively (1 versus 3, p less than 0.01). Mean times after hyperventilation until maximal bronchoconstriction were 12 +/- 4 min, 9 +/- 6 min, and 6 +/- 4 min. We also found slight bronchodilation during the first 4 min of hyperventilation. After 2 and 4 min of hyperventilation, the FEV1 was 103 +/- 5% and 103 +/- 3% of baseline, respectively (both p less than 0.05, compared to baseline). We conclude that increasing the duration of hyperventilation delays the onset of bronchoconstriction but causes greater bronchoconstriction once the hyperventilation is stopped. These results suggest that either hyperventilation itself inhibits bronchoconstriction or that the mechanisms that induce ...Continue Reading
Citations
Jan 1, 1994·European Journal of Applied Physiology and Occupational Physiology·I RønnestadA Hope
Jun 1, 1994·Biofeedback and Self-regulation·F CeugnietJ Gallego
Feb 10, 2000·Toxicology·D A Lawrence, D Kim
May 12, 1994·The New England Journal of Medicine·E R McFadden, I A Gilbert
Sep 1, 1992·Thorax·S D Anderson, E Daviskas
Aug 1, 1991·The American Review of Respiratory Disease·A N FreedC E Stream
Nov 16, 2004·American Journal of Respiratory and Critical Care Medicine·Kim G Nielsen, Hans Bisgaard
May 1, 1995·The Journal of Clinical Investigation·A GarlandJ Solway
Nov 1, 1995·Chest·K M HurwitzY Y Phillips
Jun 1, 1996·Chest·G J ArgyrosY Y Phillips
Sep 1, 1996·Chest·H O KoskelaH O Tukiaineu
Aug 1, 1995·Chest·G J ArgyrosY Y Phillips
Jun 19, 2007·Chest·Daphna VilozniArie Augarten
Feb 1, 1997·Current Problems in Pediatrics·C Randolph
Jun 6, 2009·Respiratory Medicine·Daphna VilozniOri Efrati
Jul 1, 1993·Respiratory Medicine·S Godfrey, E Bar-Yishay
Jan 31, 2007·Pediatric Pulmonology·Karl P SylvesterAnne Greenough
May 15, 2002·Environmental Health Perspectives·Subhash C Arya
May 11, 2002·Environmental Health Perspectives·David A Lawrence
May 15, 2002·Environmental Health Perspectives·Lorenz Rhomberg
Sep 1, 1994·European Journal of Clinical Investigation·H K Makker, S T Holgate
Jan 10, 2019·BMJ Open Respiratory Research·Sarah KochMichael Stephen Koehle
Oct 29, 2000·Journal of Applied Physiology·O E SumanK C Beck
Mar 15, 2001·Journal of Applied Physiology·O E Suman, K C Beck
Sep 14, 1999·Journal of Applied Physiology·O E SumanA W Reddan