PMID: 8600364Mar 9, 1996Paper

The time-course of micronucleated polychromatic erythrocytes in mouse bone marrow and peripheral blood

Mutation Research
L Abramsson-ZetterbergJ Grawé

Abstract

The time-course of micronucleated polychromatic erythrocytes (MPCE) in mouse bone marrow and peripheral blood, induced by an acute 0.1 Gy dose of X-rays, was determined using flow cytometric analysis, which made frequent sampling possible and allowed use of a dose low enough not to affect erythroid cell proliferation. The frequency of MPCE (fMPCE) began to increase in the bone marrow at 10 h after irradiation and reached a maximum at 28 h after irradiation. In the peripheral blood fMPCE began to increase at 20 h after irradiation and peaked at about 40 h after irradiation. The time-course found is discussed on the basis of data on the differentiation of erythroid cells. The results indicate that the micronuclei registered in polychromatic erythrocytes may originate from lesions induced not only during the last cell cycle but also during earlier ones. After an acute dose of 1.0 Gy of X-rays the maximum fMPCE was delayed both in bone marrow and peripheral blood reflecting an effect on the cell cycle progression of erythroblasts.

References

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Citations

Mar 25, 2011·Environmental Health and Preventive Medicine·Chuancheng WuKanehisa Morimoto
Jan 4, 2001·Mathematical Biosciences·O HyrienP Sanders
Sep 24, 2002·Toxicology Letters·Lilianne Abramsson-Zetterberg, Premysl Slanina
Jan 22, 1998·Mutation Research·L Abramsson-ZetterbergG Zetterberg
Jun 20, 2007·International Journal of Radiation Biology·Jukka JuutilainenJorma Mäki-Paakkanen
Apr 13, 2010·Mutation Research·Lilianne Abramsson-ZetterbergRoland Mattsson
Apr 10, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Maria A AnderssonBjörn E Hellman
Dec 18, 2004·Toxicology Letters·Lilianne Abramsson-Zetterberg, Kettil Svensson
Jan 26, 2005·Mutation Research·Louise J K Durling, Lilianne Abramsson-Zetterberg
Jan 18, 2011·Toxicology Letters·Lilianne Abramsson-Zetterberg, Kettil Svensson
Feb 5, 2013·Mutation Research·Lilianne Abramsson-ZetterbergSalomon Sand
Aug 21, 2013·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Aneta GajowikMałgorzata M Dobrzyńska
Jun 12, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Lilianne Abramsson-Zetterberg, Nils-Gunnar Ilbäck
Jan 17, 2007·Toxicology Letters·Louise J K DurlingLilianne Abramsson-Zetterberg
Sep 21, 2016·International Journal of Molecular Sciences·Laura A BannisterDmitry Y Klokov
Jul 24, 2008·Dose-response : a Publication of International Hormesis Society·Brenda E Rodgers, Kristen M Holmes
Nov 2, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Dana L ShueyRonald J Gerson
Sep 29, 2005·Radiation Research·Polly Y ChangRupa Doppalaudi

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