DOI: 10.1101/495960Dec 13, 2018Paper

The time course of recognition memory impairment and glial pathology in the hAPP-J20 mouse model of Alzheimer's disease.

BioRxiv : the Preprint Server for Biology
Kamar E Ameen-AliJason Berwick

Abstract

The role of cellular changes in the neurovascular unit is increasingly being investigated to understand the pathogenesis of Alzheimers disease. The aim of the current study was to determine the time course of recognition memory impairment in the J20 mouse model of AD, in relation to neuroinflammatory responses and the pathology of Aβ. Male hAPP-J20 and wild-type mice were assessed at 3, 6, 9, and 12 months of age. The spontaneous object recognition (SOR) task provided a measure of memory, with assessment of both a short delay (1 min) and a long delay (4 hrs). Immunohistochemistry was used to characterise Aβ-deposition, and quantify astrocyte and microglial responses. At all ages tested J20 mice had impaired long-term, but preserved short-term, recognition memory. Wild-types demonstrated preserved long-term memory up to 9 months of age, and preserved short-term memory at all ages tested. Plaque pathology in the J20 mice was present from 6 months onwards, with co-localisation of reactive microglia and activated astrocytes. Reactive microglia and astrocyte activation in the hippocampus were significantly greater in the J20 mice at 9 months, compared to wild-types. This study contributes to our understanding of the pathological and...Continue Reading

Related Concepts

Alzheimer's Disease
Astrocytes
Cognition
Hippocampus (Brain)
Immunohistochemistry
Memory
Neuroglia
Microglia
Evaluation
Disease Progression

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