PMID: 169486Jul 17, 1975Paper

The time course of the effects of beta- and alpha-adrenoceptor stimulation by isoprenaline and methoxamine on the contractile force and cAMP level of the isolated rabbit papillary muscle

Naunyn-Schmiedeberg's Archives of Pharmacology
H J SchümannO E Brodde

Abstract

In the isolated papillary muscle of the rabbit the time course of the effects of selective beta- and alpha-adrenoceptor stimulation by isoprenaline and methoxamine, respectively, on the contractile force and on the level of 3',5'-cyclic AMP (cAMP) was determined. 1. Isoprenaline (3 times 10(-7) M) increased significantly the content of cAMP at 15 sec and elevated it to the maximal level-about twice the control value-at 30 sec after its administration, while the developed tension of the papillary muscle was also increased significantly at 15 sec and reached gradually its maximum at 90 sec. 2. Compared with isoprenaline methoxamine (10(-4) M) increased the developed tension very slowly: the maximal response was reached after 20 min. The level of cAMP, on the other hand, was changed neither before nor during the induction of the positive inotropic effect of methoxamine. 3. The phosphodiesterase inhibitor papaverine (10(-5) M) inhibited the PDE activity of the papillary muscle by about 40% after an incubation of 1 hr, and increased the level of cAMP significantly. The effects of isoprenaline on the contractile forced and on the level of cAMP were considerably enhanced by papaverine: the content of cAMP was increased by isoprenaline...Continue Reading

References

Feb 1, 1975·European Journal of Pharmacology·M Endoh, H J Schümann
Sep 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·A G Gilman
Jan 1, 1971·Naunyn-Schmiedebergs Archiv Für Pharmakologie·G Pöch
Apr 1, 1973·Circulation Research·B E Sobel, S E Mayer
Jul 26, 1973·Naunyn-Schmiedeberg's Archives of Pharmacology·W R KukovetzA Wurm
May 1, 1970·The American Journal of Physiology·M Endoh, K Hashimoto
Apr 21, 1964·Naunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie·J R BLINKS

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Citations

Sep 1, 1979·Naunyn-Schmiedeberg's Archives of Pharmacology·H J Schümann, O E Brodde
Jul 1, 1984·Naunyn-Schmiedeberg's Archives of Pharmacology·R R RuffoloJ S Horng
May 5, 1978·Naunyn-Schmiedeberg's Archives of Pharmacology·J Wagner, O E Brodde
May 5, 1978·Naunyn-Schmiedeberg's Archives of Pharmacology·H J SchümannG Schramm
Aug 1, 1987·Pflügers Archiv : European journal of physiology·S Kurihara, M Konishi
May 23, 1996·European Journal of Pharmacology·A P WilliamsonR H Kennedy
Jan 1, 1988·Progress in Biophysics and Molecular Biology·H C Hartzell
May 1, 1985·Pharmacology, Biochemistry, and Behavior·R R Ruffolo
Nov 1, 1989·Journal of the American College of Cardiology·M W KronenbergG C Friesinger
Oct 1, 1986·Journal of the American College of Cardiology·M F MaturiR E Patterson
Sep 1, 1983·Circulation Research·L Belardinelli, G Isenberg
Nov 1, 1992·Circulation Research·K KiuchiS F Vatner
Feb 1, 1979·Circulation Research·G I Drummond, D L Severson
Jun 24, 1976·Nature·M EndohH J Schümann
Jun 27, 2006·Journal of Pharmacological Sciences·Masao Endoh

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