Abstract
Midazolam has hypnotic and sedative activities, which may be mediated by different neuronal structures. We investigated the time course effect of a hypnotic dose of midazolam on conscious motor behavior and on patterns of brain metabolism. Loss of nociceptive reflexes and impairment of spontaneous locomotor activity were used as indices for the hypnotic and sedative effects of midazolam, and the regional cerebral metabolic rates for glucose (rCMRglc) were used as indices of neuronal effects of midazolam. Locomotor activity was measured with a monitor and rCMRglc were measured with the quantitative autoradiographic [(14)C]2-deoxyglucose procedure in 62 brain regions of Fischer-344 rats at 2, 30, 60, 120, and 180 min after i.v. administration of saline or midazolam 5 mg/kg. After midazolam administration, rats were anesthetized at 2 min, awake but severely impaired at 30 min and slowly recovering motor activity thereafter. Anesthesia was associated with widespread rCMRglc decreases (59 areas affected, 38% mean decrease). Recovery of consciousness was associated with normalizing rCMRglc in visual, auditory, and somatosensory cortices and in the locus coeruleus (47 regions affected, 31% decrease). Recovery of motor activity was par...Continue Reading
References
May 1, 1977·Journal of Neurochemistry·L SokoloffM Shinohara
Sep 1, 1990·Anesthesiology·M DamL Battistin
Oct 1, 1988·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T T SoncrantS I Rapoport
Sep 1, 1986·Neuroscience·P A KellyJ McCulloch
Apr 1, 1983·Neuropharmacology·J P LaurentW Haefely
Jan 1, 1983·British Journal of Clinical Pharmacology·M Gerecke
Jan 7, 1982·Brain Research·M Del FiaccoA C Cuello
Sep 1, 1982·Journal of Neurochemistry·P A Kelly, J McCulloch
Apr 1, 1995·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·N D VolkowA P Wolf
Jul 6, 1993·European Journal of Pharmacology·A ImperatoG Biggio
Feb 1, 1993·British Journal of Anaesthesia·K TakadaN Koshikawa
Jan 1, 1996·Life Sciences·U Freo
Feb 21, 1997·Neuroscience Letters·S KaurB N Mallick
Sep 1, 1997·Neuroscience·T KottiR Miettinen
Nov 20, 1997·Anesthesiology·R A VeselisR G Blasberg
Dec 14, 1999·Psychopharmacology·T KubotaA Matsuki
Oct 6, 2000·Science·K LöwU Rudolph
May 29, 2002·Neuroscience·N MoraguesM Garret
Jul 12, 2002·Journal of Neural Transmission·U FreoL Battistin
Aug 10, 2002·Anesthesiology·Kaike K KaistiHarry Scheinin
Aug 27, 2002·Nature Neuroscience·L E NelsonM Maze
Oct 24, 2002·British Journal of Anaesthesia·L PainP Oberling
Dec 28, 2002·Progress in Neuro-psychopharmacology & Biological Psychiatry·José Francisco NavarroMercedes Martín-López
Feb 28, 2003·The Journal of Pharmacology and Experimental Therapeutics·J E KralicG E Homanics
Jun 15, 2004·NeuroImage·Mathias SchreckenbergerGerhard Gründer
Feb 26, 2005·Anesthesiology·Yuki SatoNorimasa Seo
Sep 28, 2005·Progress in Brain Research·Michael T Alkire, Jason Miller
Sep 29, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·David M DevilbissBarry D Waterhouse
Nov 1, 2006·Current Pharmaceutical Design·Christian GrasshoffBernd Antkowiak
Jan 1, 1982·Neurochemistry International·M K Rahman, T Nagatsu
Citations
Oct 17, 2009·Biochemical Pharmacology·Heather A Mitchell, David Weinshenker
Feb 24, 2015·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Yusuke OsakiRyuji Kaji
Jul 16, 2014·Behavioural Brain Research·C Busettini, M A Frölich
May 12, 2016·Journal of Neurochemistry·Gerald A Dienel, Nancy F Cruz
Sep 26, 2015·Pharmacological Reviews·Esa R KorpiGavin S Dawe