PMID: 9646156Jul 1, 1998Paper

The time-related expression of p53 protein in human skin wounds--a quantitative immunohistochemical analysis

International Journal of Legal Medicine
R HausmannP Betz

Abstract

The time-dependent expression of p53 protein during wound healing has been investigated by immunochemistry in fibroblastic cells of skin wounds ranging between a few minutes and 11 weeks old. When compared to uninjured skin, an increased expression of p53 was found earliest in a wound with a postinfliction interval of 3 days. The ratio (r) of positively stained cells in relation to the total number of fibroblastic cells in the wound area of this specimen was about 0.2. A considerable increase in the expression of p53 (r > 0.5) was first found in a wound aged 8 days and in wounds with postinfliction intervals ranging between 3 and 11 weeks, where the ratio of positive cells was between 0.40 and 0.64. Therefore, it can be calculated that r-values of at least 0.5 indicate a postinfliction interval of approximately 1 week or more. Since comparably low numbers of positively stained fibroblastic cells were found in specimens with an advanced wound duration, reliable information for a forensic wound age estimation can only be provided by positive results.

Citations

Nov 5, 2004·International Journal of Legal Medicine·Takahito HayashiToshikazu Kondo
Sep 15, 2010·International Journal of Legal Medicine·Rossana Cecchi
Sep 9, 2000·Forensic Science International : Synergy·T Ohshima
Jul 27, 2001·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·X ZhuZ Wang
Feb 6, 2007·Legal Medicine·Toshikazu Kondo
Mar 16, 2012·Experimental Dermatology·Ellen HeitzerPeter Wolf
Jul 4, 2015·Aging Cell·Reuben H KimNo-Hee Park
Sep 15, 2004·Forensic Science International : Synergy·M Oehmichen
Jul 26, 2005·Forensic Science International : Synergy·Toru NakajimaHirotaro Iwase
Sep 3, 2016·Journal of Forensic and Legal Medicine·İsmail Birincioğluİmran İnce
Jan 5, 2002·The American Journal of Forensic Medicine and Pathology·K PsaroudakisM N Michalodimitrakis
May 17, 2003·The Journal of Biological Chemistry·Anna A SablinaBoris P Kopnin
Oct 23, 2019·International Journal of Molecular Medicine·Han CaiJinghe Lang
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marek KonopJoanna Czuwara

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