PMID: 16523687Mar 10, 2006Paper

The time scale in poxvirus evolution

Molekuliarnaia biologiia
Igor V Babkin, S N Shchelkunov

Abstract

Unlike vertebrates and RNA-containing viruses, the objective estimate of molecular clock for DNA-containing viruses was so far absent. An extended central conservative genomic region of orthopoxviruses (about 102 kbp) and the sequence of DNA polymerase gene (about 3 kbp) of the viruses belonging to various genera from the family Poxviridae were analyzed. During this analysis, the known dating of variola virus (VARV) transfer from West Africa to South America (XVI century) and our own data on close phylogenetic relations between the modem West African and South American VARV isolates were used. As a result of this work, it was calculated for the first time that the rate of mutation accumulation in these DNA-containing viruses amounted to 0.9-1.2 x 10(-6) substitutions per site per year. The poxviruses started separating from the ancestor virus to form the modem genera approximately 500 thousand years ago; the ancestor of the genus Orthopoxvirus separated about 300 thousand years ago; and its division into the modem studied species took place approximately 14 thousand years ago.

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Citations

Sep 22, 2009·Archives of Virology·Fernando AldaIgnacio Doadrio
Nov 3, 2009·Archives of Virology·Sergei N Shchelkunov
Oct 17, 2008·Molekuliarnaia biologiia·I V BabkinS N Shchelkunov
Apr 8, 2014·Viruses·Kate S Baker, Pablo R Murcia
Oct 30, 2009·PloS One·Ginny L EmersonDarin S Carroll
Nov 26, 2009·Avian Pathology : Journal of the W.V.P.A·Keisuke SaitoTokuma Yanai
Mar 14, 2009·Comptes rendus biologies·Olivier VerneauMathieu Badets
Aug 18, 2012·Advances in Virology·Sergei N Shchelkunov
Aug 2, 2015·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Guillaume Le Loc'hMariette F Ducatez
Oct 29, 2013·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Sherry L HallerStefan Rothenburg
Apr 7, 2010·Molekuliarnaia genetika, mikrobiologiia i virusologiia·I V Babkin, I N Babkina
Jan 1, 2019·Voprosy virusologii·S N Shchelkunov, G A Shchelkunova
Oct 2, 2008·Genetika·I V Babkin, S N Shelkunov
Mar 13, 2015·Viruses·Igor V Babkin, Irina N Babkina
Nov 18, 2016·Cellular and Molecular Life Sciences : CMLS·Ilya M TereninIvan N Shatsky
Jan 14, 2011·Intervirology·Igor V Babkin, Irina N Babkina
Jun 21, 2020·Biomolecules·Kseniya A LashkevichSergey E Dmitriev
Feb 18, 2018·The Journal of Biological Chemistry·Denis SusorovElena Alkalaeva

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