Nov 6, 2018

The Time Scale of Evolution

BioRxiv : the Preprint Server for Biology
Diogo Santos, Lilia Perfeito


Fitness is a measure of how quickly alleles change in frequency under natural selection. Time is always implicit in evolutionary models but its units are rarely made explicit. When measuring phenotypes such as absolute growth rate, the units of measurement need to be made explicit. By contrasting measures of fitness and growth rate, we uncovered a curious effect, by which evolutionary time runs at different speeds depending on how restricted population growth is. In other words, when the generation time of a population is externally imposed, relative fitness per generation is no longer an accurate measure of differences between genotypes. We explore this effect and describe how it affects selective sweeps, probability of fixation of beneficial mutations and adaptation dynamics. Moreover, we show that different populations cannot be compared unless they share a common reference and that our inference of epistasis can be biased by this temporal effect. Finally, we suggest less biased ways to measure selection in experimental evolution.

  • References
  • Citations


  • We're still populating references for this paper, please check back later.
  • References
  • Citations


  • This paper may not have been cited yet.

Mentioned in this Paper

Sample Fixation
Contrast Used
Fixation - Action
Population Group
Biological Evolution
Epistasis, Genetic

About this Paper

Related Feeds

BioRxiv & MedRxiv Preprints

BioRxiv and MedRxiv are the preprint servers for biology and health sciences respectively, operated by Cold Spring Harbor Laboratory. Here are the latest preprint articles (which are not peer-reviewed) from BioRxiv and MedRxiv.