The timing and location of glial cell line-derived neurotrophic factor expression determine enteric nervous system structure and function.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Hongtao WangR O Heuckeroth

Abstract

Ret signaling is critical for formation of the enteric nervous system (ENS) because Ret activation promotes ENS precursor survival, proliferation, and migration and provides trophic support for mature enteric neurons. Although these roles are well established, we now provide evidence that increasing levels of the Ret ligand glial cell line-derived neurotrophic factor (GDNF) in mice causes alterations in ENS structure and function that are critically dependent on the time and location of increased GDNF availability. This is demonstrated using two different strains of transgenic mice and by injecting newborn mice with GDNF. Furthermore, because different subclasses of ENS precursors withdraw from the cell cycle at different times during development, increases in GDNF at specific times alter the ratio of neuronal subclasses in the mature ENS. In addition, we confirm that esophageal neurons are GDNF responsive and demonstrate that the location of GDNF production influences neuronal process projection for NADPH diaphorase-expressing, but not acetylcholinesterase-, choline acetyltransferase-, or tryptophan hydroxylase-expressing, small bowel myenteric neurons. We further demonstrate that changes in GDNF availability influence intesti...Continue Reading

References

Dec 22, 1991·The Journal of Comparative Neurology·T D PhamT P Rothman
Nov 1, 1981·Journal of Pharmacological Methods·M S MillerT F Burks
Jul 4, 1996·Nature·M W MooreA Rosenthal
Feb 1, 1997·Current Opinion in Neurobiology·M D Gershon
Jun 24, 1997·Proceedings of the National Academy of Sciences of the United States of America·D J CreedonE M Johnson
Mar 30, 1999·Brain Research. Molecular Brain Research·L FengB Lu
Feb 19, 2000·Current Opinion in Neurobiology·R H BalohJ Milbrandt
Jun 28, 2000·Journal of the Autonomic Nervous System·J B Furness
Jan 11, 2001·Developmental Biology·H M YoungD F Newgreen
Apr 16, 2002·Nature Genetics·Stacey B GabrielAravinda Chakravarti
Apr 16, 2002·Nature Genetics·Eberhard Passarge
May 4, 2002·Nature Reviews. Neuroscience·Matti S Airaksinen, Mart Saarma
May 15, 2002·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Donald Newgreen, Heather M Young
May 23, 2002·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Donald Newgreen, Heather M Young
Jun 14, 2003·Gastroenterology·Martin SteinkampMax Reinshagen
Aug 16, 2003·Science·Toshihide IwashitaSean J Morrison
Oct 1, 1954·The Journal of Comparative Neurology·C L YNTEMA, W S HAMMOND
Jun 10, 2004·Journal of Pediatric Gastroenterology and Nutrition·Cheryl E Gariepy
May 22, 2007·Nature Reviews. Neuroscience·Tiffany A Heanue, Vassilis Pachnis
Oct 30, 2007·Journal of Medical Genetics·J AmielUNKNOWN Hirschsprung Disease Consortium

❮ Previous
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Citations

Jan 28, 2012·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Heyun GaoTianqi Zhu
Dec 12, 2012·Nature Reviews. Gastroenterology & Hepatology·Florian ObermayrHeather M Young
Oct 1, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Alcmène ChalazonitisEric J Huang
Feb 2, 2016·Neurobiology of Disease·Carlos F Ibáñez, Jaan-Olle Andressoo
Mar 30, 2010·Autonomic Neuroscience : Basic & Clinical·Heather M YoungColin R Anderson
Jul 19, 2013·The Journal of Comparative Neurology·Annette J BergnerHeather M Young
Feb 27, 2013·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·F ObermayrH M Young
Jan 26, 2011·Glia·Gabrio Bassotti, Vincenzo Villanacci
Mar 22, 2016·Developmental Biology·Robert O Heuckeroth, Karl-Herbert Schäfer
Jun 27, 2013·Wiley Interdisciplinary Reviews. Developmental Biology·Sonja J McKeownHeather M Young
Jan 31, 2013·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·I ZaitounA Gosain
May 3, 2013·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·C Harrison, I T Shepherd
Apr 1, 2015·Molecular and Cellular Neurosciences·Paola BrunIgnazio Castagliuolo
Jun 29, 2013·Developmental Biology·Elizabeth C Wright-JinRobert O Heuckeroth
Feb 1, 2012·Developmental Biology·Valentina SasselliAlan J Burns
Feb 11, 2015·The Journal of Clinical Investigation·Marina AvetisyanRobert O Heuckeroth
Apr 27, 2016·Developmental Biology·Toshihiro UesakaHideki Enomoto
May 29, 2016·Developmental Biology·M M HaoW Boesmans
Jun 10, 2016·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A M TouréN Pilon
Jul 21, 2016·The Journal of Physiology·Catherine Le Berre-ScoulHélène Boudin
Nov 1, 2016·Stem Cells and Development·Qiliang JiangXueyin Shi
Oct 13, 2018·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·John P RussellBeverley Greenwood-Van Meerveld
Apr 19, 2019·JCI Insight·Ellen M SchillRobert O Heuckeroth
Sep 1, 2012·Expert Review of Endocrinology & Metabolism·Furio PaciniLori Wirth
May 4, 2013·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jonathan I Lake, Robert O Heuckeroth
Jan 25, 2014·American Journal of Physiology. Gastrointestinal and Liver Physiology·Simon Musyoka MwangiShanthi Srinivasan
Aug 22, 2015·American Journal of Physiology. Gastrointestinal and Liver Physiology·Michael MeirNicolas Schlegel
Nov 10, 2017·Nature Reviews. Disease Primers·Sue E CrawfordMary K Estes
May 29, 2020·Cognitive, Affective & Behavioral Neuroscience·Maud Grol, Rudi De Raedt
Apr 3, 2014·Biological cybernetics·Günther PalmAlmut Schüz
Jan 9, 2018·Physiotherapy Theory and Practice·Ragnhild B HåkstadGunn Kristin Øberg
Oct 10, 2015·American Journal of Physiology. Gastrointestinal and Liver Physiology·Calvin S PohlAdam J Moeser
Jul 27, 2018·Nature Reviews. Neuroscience·Meenakshi Rao, Michael D Gershon

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