The timing of discharge from the intensive care unit and subsequent mortality. A prospective, multicenter study

American Journal of Respiratory and Critical Care Medicine
J SantamariaDischarge and Readmission Evaluation (DARE) Study

Abstract

Previous studies suggested an association between after-hours intensive care unit (ICU) discharge and increased hospital mortality. Their retrospective design and lack of correction for patient factors present at the time of discharge make this association problematic. To determine factors independently associated with mortality after ICU discharge. This was a prospective, multicenter, binational observational study involving 40 ICUs in Australia and New Zealand. Participants were consecutive adult patients discharged alive from the ICU between September 2009 and February 2010. We studied 10,211 patients discharged alive from the ICU. Median age was 63 years (interquartile range, 49-74), 6,224 (61%) were male, 5,707 (56%) required mechanical ventilation, and their median Acute Physiology and Chronic Health Evaluation III risk of death was 9% (interquartile range, 3-25%). A total of 8,539 (83.6%) patients were discharged in-hours (06:00-18:00) and 1,672 (16.4%) after-hours (18:00-06:00). Of these, 408 (4.8%) and 124 (7.4%), respectively, subsequently died in hospital (P < 0.001). After risk adjustment for markers of illness severity at time of ICU discharge including limitations of medical therapy (LOMT) orders, the time of disc...Continue Reading

References

Oct 1, 1985·Critical Care Medicine·W A KnausJ E Zimmerman
Nov 24, 1993·JAMA : the Journal of the American Medical Association·S LemeshowJ Rapoport
Dec 22, 1993·JAMA : the Journal of the American Medical Association·J R Le GallF Saulnier
May 3, 2000·Lancet·C Goldfrad, K Rowan
Feb 11, 2003·Critical Care Medicine·Elie AzoulayJean-François Timsit
Sep 11, 2003·The Medical Journal of Australia·Rinaldo BellomoGeoffrey Gutteridge
Nov 6, 2003·Intensive Care Medicine·Ari UusaroEsko Ruokonen
Nov 13, 2004·Anaesthesia and Intensive Care·G J DukeJ H Briedis
Apr 6, 2006·The Medical Journal of Australia·Antony E Tobin, John D Santamaria
Nov 1, 2006·Critical Care Medicine·Fran A Priestap, Claudio M Martin
Nov 21, 2007·Anaesthesia and Intensive Care·D V PilcherG Hart
Jul 31, 2008·Critical Care Medicine·Tarik HananeBekele Afessa
Aug 30, 2008·Journal of Critical Care·Kevin B LauplandH Thomas Stelfox
Jul 15, 2011·The New England Journal of Medicine·Daryl A JonesRinaldo Bellomo
May 9, 2012·Australian Critical Care : Official Journal of the Confederation of Australian Critical Care Nurses·Suzanne EliottRuth Endacott
Dec 25, 2013·International Journal of Epidemiology·Fiona Imlach GunasekaraTony Blakely
Mar 8, 2014·International Journal of Epidemiology·Clemma J Muller, Richard F MacLehose
Mar 19, 2014·JAMA : the Journal of the American Medical Association·Kirsi-Maija KaukonenRinaldo Bellomo
Aug 15, 2014·Intensive Care Medicine·Dashiell GantnerDavid Pilcher

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Citations

Nov 26, 2015·Intensive Care Medicine·Andrew A KramerJack E Zimmerman
Jul 2, 2016·American Journal of Respiratory and Critical Care Medicine·Martin DresGerard F Curley
Aug 16, 2016·Intensive Care Medicine·Ignacio Martin-LoechesUNKNOWN ICON Investigators
Jan 15, 2016·BMJ Quality & Safety·Andre C K B Amaral, Brian H Cuthbertson
Jul 28, 2017·PloS One·Ravindranath TiruvoipatiUNKNOWN Australia and New Zealand Intensive Care Society (ANZICS) Clinical Trials Group
Mar 29, 2018·Critical Care : the Official Journal of the Critical Care Forum·Oleksa G RewaSean M Bagshaw
Mar 31, 2018·Critical Care Medicine·John SantamariaDavid Reid
Aug 2, 2018·Intensive Care Medicine·Christian Fynbo Christiansen, Hans Flaatten
Sep 16, 2016·Critical Care Medicine·John D SantamariaUNKNOWN Discharge and Readmission Evaluation (DARE) Study Group
Jul 29, 2020·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Nicholas A FergussonDonald E G Griesdale
Feb 26, 2016·Journal of Intensive Care·Krishnaswamy SundararajanCampbell Thompson
Jul 23, 2020·Revista latino-americana de enfermagem·Michele Elisa Weschenfelder HervéMaria Alice Dias Da Silva Lima
Dec 14, 2018·PloS One·Thiago Domingos CorrêaDanilo Teixeira Noritomi
Dec 3, 2016·Critical Care : the Official Journal of the Critical Care Forum·Si YangLijun Ma
May 2, 2015·American Journal of Respiratory and Critical Care Medicine·Scott D Halpern
Aug 2, 2017·Critical Care : the Official Journal of the Critical Care Forum·Bourke Tillmann, Hannah Wunsch
Jan 8, 2021·Critical Care : the Official Journal of the Critical Care Forum·Sarah VollamPeter Watkinson
Jan 7, 2021·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·John BasmajiRaymond Kao
May 18, 2019·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Shrikanth Srinivasan
May 18, 2019·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Sharmila ChatterjeeS K Todi

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