Abstract
The understanding of the cellular responses implicated in perinatal brain damages and the characterization of the various mechanisms involved might open new horizons for understanding the time of onset of a brain hypoxic-ischemic lesion and for effective therapeutic strategies. We performed an immunohistochemical investigation on brain and brainstem sections of 47 peripartum deaths. The gradation and localization of the expression of antibodies such as TNFalpha, IL-1beta, IL-6, HSPs, beta APP, anti-TrypH, GAP43, GFAP, COX2, ORP-150, could be correlated with an hypoxic-ischemic damage to document a significant correlation between response and the time of onset acute (</=8 hs) or non-acute (>/=8 hs </=48 hs). In non-acute cases HSP70 reaction was prominent in the neuron cytoplasm, while in acute cases a mild reaction was evident in sporadic fields. HSP90 exhibited a similar pattern of positivity as HSP70. In acute group, ORP150 expressed an intense reaction showing a granular pattern in the cytoplasm of the neurons in the cortex of the infarcted areas. In non-acute group the positive reaction was more intense in astrocytes and less extended in neurons. COX2 reaction exhibited the strongest positive reaction in the neuronal cell b...Continue Reading
References
Nov 20, 1998·Neuropathology and Applied Neurobiology·K Baiden-AmissahP M Cox
Mar 7, 2001·Nature Medicine·M TamataniM Tohyama
Jun 8, 2001·The Journal of Pediatrics·N Paneth
Nov 1, 2002·Acta Neuropathologica·Hidekazu TomimotoHerbert Budka
Dec 31, 2002·BJOG : an International Journal of Obstetrics and Gynaecology·Catherine GreenwoodAnn Johnson
Jul 31, 2003·Neuropathology and Applied Neurobiology·N BenjellounC Charriaut-Marlangue
Jun 9, 2004·Best Practice & Research. Clinical Obstetrics & Gynaecology·Barry S Schifrin
Jul 15, 2004·Seminars in Neonatology : SN·Waney Squier, Frances M Cowan
Sep 7, 2005·Postgraduate Medical Journal·Y ChengR H Wu
Apr 26, 2007·Seminars in Diagnostic Pathology·Rebecca D Folkerth
Oct 10, 2007·International Journal of Legal Medicine·Emanuela TurillazziVittorio Fineschi
Aug 19, 2008·Brain Research·Xinhua ZhanFrank R Sharp
Nov 11, 2008·Brain Research·Jessie S TruettnerBingren Hu
Nov 28, 2008·BJOG : an International Journal of Obstetrics and Gynaecology·L F NielsenP Thorsen
Dec 17, 2008·American Journal of Obstetrics and Gynecology·Roger K Freeman
Dec 17, 2008·American Journal of Obstetrics and Gynecology·Ernest M GrahamHarold E Fox
May 16, 2009·Current Neurovascular Research·Distefano GiuseppeAmato Maurizio
Oct 3, 2009·Journal of Neuroscience Research·Irene RiezzoVittorio Fineschi
Citations
Oct 3, 2013·International Journal of Molecular Sciences·Margherita NeriVittorio Fineschi
Sep 24, 2011·Neuroscience Letters·Hidetoshi TaniguchiKatrin Andreasson
May 21, 2013·Journal of Neuroscience Research·Dan HuYan Qu
Sep 16, 2016·Neural Regeneration Research·Yuan LiuYan Qu
Jan 8, 2016·Molecular and Cellular Biochemistry·Chun-Lei LiuKun-Lun He
Oct 26, 2016·Molecular Medicine Reports·Monica MontesiAlina Beraudi
Sep 9, 2017·Mediators of Inflammation·Vittorio FineschiPaola Frati
Aug 30, 2021·Forensic Science International : Synergy·Federico MidiriMassimo Midiri