The timing of perinatal hypoxia/ischemia events in term neonates: a retrospective autopsy study. HSPs, ORP-150 and COX2 are reliable markers to classify acute, perinatal events.

Diagnostic Pathology
Irene RiezzoVittorio Fineschi

Abstract

The understanding of the cellular responses implicated in perinatal brain damages and the characterization of the various mechanisms involved might open new horizons for understanding the time of onset of a brain hypoxic-ischemic lesion and for effective therapeutic strategies. We performed an immunohistochemical investigation on brain and brainstem sections of 47 peripartum deaths. The gradation and localization of the expression of antibodies such as TNFalpha, IL-1beta, IL-6, HSPs, beta APP, anti-TrypH, GAP43, GFAP, COX2, ORP-150, could be correlated with an hypoxic-ischemic damage to document a significant correlation between response and the time of onset acute (</=8 hs) or non-acute (>/=8 hs </=48 hs). In non-acute cases HSP70 reaction was prominent in the neuron cytoplasm, while in acute cases a mild reaction was evident in sporadic fields. HSP90 exhibited a similar pattern of positivity as HSP70. In acute group, ORP150 expressed an intense reaction showing a granular pattern in the cytoplasm of the neurons in the cortex of the infarcted areas. In non-acute group the positive reaction was more intense in astrocytes and less extended in neurons. COX2 reaction exhibited the strongest positive reaction in the neuronal cell b...Continue Reading

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Citations

Sep 24, 2011·Neuroscience Letters·Hidetoshi TaniguchiKatrin Andreasson
Oct 26, 2016·Molecular Medicine Reports·Monica MontesiAlina Beraudi
Sep 9, 2017·Mediators of Inflammation·Vittorio FineschiPaola Frati
Aug 30, 2021·Forensic Science International : Synergy·Federico MidiriMassimo Midiri

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Methods Mentioned

BETA
confocal microscopy

Software Mentioned

SPSS

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