PMID: 8938124Nov 1, 1996Paper

The timSL mutant of the Drosophila rhythm gene timeless manifests allele-specific interactions with period gene mutants

Neuron
J E RutilaM Rosbash

Abstract

To identify new components of the Drosophila circadian clock, we screened chemically mutagenized flies for suppressors or enhancers of the long periods characteristic of the period (per) mutant allele perL. We isolated a novel mutant that maps to the rhythm gene timeless (tim). This novel allele, timSL, alters the temporal pattern of perL protein nuclear localization and restores temperature compensation to perL flies. timSL more generally manifests specific interactions with different per alleles. The identification of this first period-altering tim allele provides further evidence that TIM is a major component of the clock, and the allele-specific interactions with PER provide evidence that the PER/TIM heterodimer is a unit of circadian function. Although timSL fails to restore PER-L/TIM temperature insensitivity in yeast, it alters the TIM phosphorylation pattern during the late night. The effects on phosphorylation suggest that timSL functions as a partial bypass suppressor of perL and provide evidence that the TIM phosphorylation program contributes to the circadian timekeeping mechanism.

References

Dec 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·P E HardinM Rosbash
Sep 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·R J Konopka, S Benzer
Mar 15, 1994·Proceedings of the National Academy of Sciences of the United States of America·I EderyM Rosbash

❮ Previous
Next ❯

Citations

Dec 18, 2002·Journal of Neurobiology·Ralf Stanewsky
May 3, 2001·Journal of Neurobiology·G K WangA Sehgal
Jan 18, 2007·Pflügers Archiv : European journal of physiology·Ben Collins, Justin Blau
Sep 1, 2000·Brain Research. Brain Research Reviews·K E van EsseveldtG J Boer
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Yasushi IsojimaHiroki R Ueda
Feb 22, 2001·Annual Review of Physiology·J A Williams, A Sehgal
May 1, 2009·PLoS Biology·Johannes LandskronRalf Stanewsky
Mar 21, 2001·Pharmacogenomics·P M Nolan
May 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·A A PeixotoC P Kyriacou
May 7, 1999·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·T TakumiH Okamura
May 13, 1999·Journal of Neurogenetics·J C Hall
Dec 9, 1998·Chronobiology International·C Helfrich-FörsterU Homberg
Jan 5, 2002·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·E L Meyer-Bernstein, A Sehgal
Oct 23, 1998·Journal of Biological Rhythms·J E RutilaM Rosbash
Apr 29, 1998·Journal of Biological Rhythms·T Roenneberg, M Merrow
Sep 6, 2000·Nature Genetics·K Wager-Smith, S A Kay
May 5, 2017·Genetics·Joao Picao-OsorioClaudio R Alonso

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.