The Tinsley LCR Databridge Model 6401 and electrical impedance measurements to evaluate skin integrity in vitro

Toxicology in Vitro : an International Journal Published in Association with BIBRA
William J Fasano, P M Hinderliter

Abstract

Electrical impedance is used to confirm skin integrity for in vitro dermal regulatory testing and as a tool to evaluate skin condition to determine the irritation and corrosion potential of various chemicals and personal care products. In this experiment, samples of dermatomed human skin were mounted onto static diffusion cells (0.64 cm2) maintained at 32 degrees C. Following equilibration with 0.9% saline in the donor and receptor chambers, an impedance measurement was taken with a Tinsley LCR Databridge Model 6401 set in the resistance mode (R) and in (a) the serial-equivalent mode (SER) with an alternating current (AC) frequency of 100 hertz (Hz), (b) SER and 1000 Hz, (c) parallel-equivalent mode (PAR) and 100 Hz, and (d) PAR and 1000 Hz. With the databridge set in the SER-equivalent mode and an AC frequency of 1000 Hz, the minimum (7.2 kOmega), maximum (10.0 kOmega), and median (8.6 kOmega) impedance values exhibited a limited response range (2.8 kOmega). However, when the Tinsley 6401 was set in the PAR-equivalent mode at the lower AC frequency of 100 Hz the minimum (16.7 kOmega), maximum (134.6 kOmega), median (83.2 kOmega), and range (117.9 kOmega) of values were the highest obtained. The results confirm that the operato...Continue Reading

References

Sep 1, 1977·The Journal of Laryngology and Otology·R T RamsdenD A Moffat
Mar 1, 1976·Medical & Biological Engineering·T Yamamoto, Y Yamamoto
Jul 8, 2000·Acta Dermato-venereologica. Supplementum·J A BouwstraM Ponec
Oct 16, 2002·Journal of Pharmaceutical Sciences·N SekkatR H Guy
Nov 9, 2002·Toxicology in Vitro : an International Journal Published in Association with BIBRA·W J FasanoJ W Green
Mar 26, 2003·Toxicology in Vitro : an International Journal Published in Association with BIBRA·J R HeylingsH M Owen
Aug 1, 1998·Toxicology in Vitro : an International Journal Published in Association with BIBRA·J H FentemM Liebsch

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Citations

Aug 7, 2008·Pharmaceutical Research·Vijay Krishna RachakondaKhaled A M Gasem
Feb 22, 2005·Drug and Chemical Toxicology·W J FasanoP M Hinderliter
Apr 2, 2013·Journal of Hazardous Materials·Sharyn GaskinChristina Baxter
Feb 1, 2011·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Erick A WhiteAnnette L Bunge
Dec 26, 2006·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Sari PappinenArto Urtti
Nov 17, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Barbora JanůšováKateřina Vávrová
May 16, 2014·Biochimica Et Biophysica Acta·Petra PullmannováKateřina Vávrová
Oct 4, 2011·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Erick A WhiteAnnette L Bunge
Oct 26, 2013·Toxicology Mechanisms and Methods·Sharyn GaskinChristina Baxter
Jul 26, 2011·Toxicology in Vitro : an International Journal Published in Association with BIBRA·William J FasanoNigel P Moore
Aug 30, 2011·Toxicology in Vitro : an International Journal Published in Association with BIBRA·M OkudaA Fuchs
Aug 2, 2014·Toxicology in Vitro : an International Journal Published in Association with BIBRA·A FrankenJ L Du Plessis
Nov 26, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Michal NovotnýKateřina Vávrová
Dec 20, 2014·Toxicology Letters·A FrankenJ L Du Plessis
Jan 23, 2017·Biochimica Et Biophysica Acta. Biomembranes·Barbora ŠkolováKateřina Vávrová
Mar 5, 2016·Toxicology and Industrial Health·Sharyn GaskinChristina Baxter
Oct 23, 2019·Pest Management Science·Sharyn GaskinChristina Baxter
Oct 5, 2019·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Yasunori MiyazakiYoshiyuki Kagawa
May 5, 2017·Annals of Work Exposures and Health·Linda HeathChristina Baxter
Jul 1, 2017·Pharmaceutical Research·Monika KopečnáKateřina Vávrová
Mar 4, 2020·Scientific Reports·Andrej KováčikKateřina Vávrová
Jan 25, 2021·International Journal of Pharmaceutics·Aneta VovesnáJarmila Zbytovská
Dec 13, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Andrej KováčikKateřina Vávrová
Dec 10, 2018·ACS Biomaterials Science & Engineering·Kapil S Chaudhari, Krishnacharya G Akamanchi

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