The tip-top branching ureter

Current Opinion in Cell Biology
H Sariola, K Sainio

Abstract

Organ rudiments with their epithelial bud and adjacent mesenchyme look much the same at their initial stage of differentiation. The subsequent branching of the epithelial anlagen determines the final pattern of the organs, but the mesenchyme provides essential signals for epithelial differentiation. Glial cell line derived neurotrophic factor (GDNF) has recently been shown to regulate ureteric branching morphogenesis and is thereby the first defined signalling molecule in the embryonic metanephric kidney. GDNF is expressed by the mesenchyme, binds to the tip of the ureteric bud and functions in both bud induction and bud orientation. The active receptor complex for GDNF includes the receptor tyrosine kinase Ret and a novel class of glycosylphosphatidylinositol-linked receptors, called GDNF family receptor alpha s.

References

Dec 1, 1992·The Journal of Cell Biology·C KosekiQ al-Awqati
Dec 1, 1994·Developmental Biology·D HerzlingerA M Brown
Jun 27, 1996·Nature·P DurbecM Saarma
Jul 4, 1996·Nature·M W MooreA Rosenthal
Jul 4, 1996·Nature·J J TreanorA Rosenthal
Aug 20, 1996·Proceedings of the National Academy of Sciences of the United States of America·S VukicevicT K Sampath
Oct 1, 1996·Proceedings of the National Academy of Sciences of the United States of America·Q C VegaG R Dressler
Dec 1, 1996·Matrix Biology : Journal of the International Society for Matrix Biology·M DurbeejM Ekblom
Mar 1, 1997·Mechanisms of Development·M S Lechner, G R Dressler
Jun 10, 1997·Proceedings of the National Academy of Sciences of the United States of America·M SanicolaR L Cate

❮ Previous
Next ❯

Citations

Jun 26, 1999·Microscopy Research and Technique·M Saarma, H Sariola
Mar 8, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·A Raatikainen-AhokasH Sariola
Sep 7, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·J O HiltunenM Saarma
Aug 17, 2001·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Y LinS Vainio
Feb 19, 2000·Current Opinion in Neurobiology·R H BalohJ Milbrandt
Jun 6, 1998·Differentiation; Research in Biological Diversity·S KlothW W Minuth
Dec 16, 1998·Kidney International·Q al-Awqati, M R Goldberg
Dec 26, 2001·Current Opinion in Nephrology and Hypertension·Hannu Sariola
Dec 5, 2006·Current Opinion in Nephrology and Hypertension·Julio C MonteSanjay K Nigam
Oct 18, 2005·Molecular and Cellular Biology·Adrianne WongVassilis Pachnis
Apr 5, 2000·The Journal of Clinical Investigation·Y MiyazakiI Ichikawa
Jan 20, 2010·PLoS Genetics·Odyssé MichosFrank Costantini
Jan 7, 2014·PloS One·Suneeta S ParolyCathy Mendelsohn
Jan 8, 2000·Microvascular Research·S Kloth, C Suter-Crazzolara
Sep 29, 1999·In Vitro Cellular & Developmental Biology. Animal·K SchumacherW W Minuth
Mar 28, 2009·Journal of Theoretical Biology·Tsuyoshi HirashimaYoshihiro Morishita
Jan 26, 2006·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Frank Costantini, Reena Shakya
Aug 19, 2006·Differentiation; Research in Biological Diversity·Frank Costantini
Mar 8, 2000·Mechanisms of Development·S KuureS Vainio
Oct 16, 2009·Current Opinion in Genetics & Development·Odyssé Michos
Apr 12, 2014·Seminars in Cell & Developmental Biology·Helen Weavers, Helen Skaer
Dec 20, 2002·Developmental Biology·Richard G James, Thomas M Schultheiss
May 14, 2005·Developmental Biology·Reena ShakyaFrank Costantini
Jun 5, 1999·Molecular and Cellular Neurosciences·M S AiraksinenM Saarma
Jun 9, 2017·Development, Growth & Differentiation·Tsuyoshi HirashimaRoeland M H Merks
May 24, 2001·The Journal of Urology·E Séguier-LipszycM Peuchmaur
Jan 12, 1999·Nature Medicine·H Sariola, L Philipson
Jan 21, 2014·Physical Biology·Raphaël Clément, Benjamin Mauroy
Aug 26, 2003·Journal of the American Society of Nephrology : JASN·Christian S HaasAndrea Hartner
Feb 22, 2002·Journal of the American Society of Nephrology : JASN·José VilarMartine Leliévre-Pégorier

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Signaling by Tyrosine Kinases

Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. RTKs have been shown not only to be key regulators of normal cellular processes but also to have a critical role in the development and progression of many types of cancer. Discover the latest research on cell signaling and RTK here.