The tissue mechanics of vertebrate body elongation and segmentation

Current Opinion in Genetics & Development
Patrick McMillen, Scott A Holley

Abstract

England's King Richard III, whose skeleton was recently discovered lying ignobly beneath a parking lot, suffered from a lateral curvature of his spinal column called scoliosis. We now know that his scoliosis was not caused by 'imbalanced bodily humors', rather vertebral defects arise from defects in embryonic elongation and segmentation. This review highlights recent advances in our understanding of post-gastrulation biomechanics of the posteriorly advancing tailbud and somite morphogenesis. These processes are beginning to be deciphered from the level of gene networks to a cross-scale physical model incorporating cellular mechanics, the extracellular matrix, and tissue fluidity.

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Citations

Feb 9, 2016·Current Biology : CB·Patrick McMillenScott A Holley
Nov 14, 2015·Seminars in Cell & Developmental Biology·Martin Scaal
Aug 11, 2015·Seminars in Cell & Developmental Biology·Hervé Turlier, Jean-Léon Maître
Apr 12, 2016·Seminars in Cell & Developmental Biology·Otger Campàs
May 24, 2016·ACS Applied Materials & Interfaces·Kristin M WarrenRobert Steward
Dec 6, 2016·Nature Methods·Friedhelm SerwaneOtger Campàs
Jun 16, 2016·Development·Rajprasad LoganathanCharles D Little
Feb 5, 2019·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Feng WangXiao-Tao Wu
Aug 15, 2019·Annual Review of Cell and Developmental Biology·Alessandro MongeraOlivier Pourquié
May 22, 2021·Seminars in Musculoskeletal Radiology·Maria Pilar Aparisi GómezAlberto Bazzocchi

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