PMID: 18411149Nov 1, 1990Paper

The tissue-specific processing of Pro-ACTH/Endorphin recent advances and unsolved problems

Trends in Endocrinology and Metabolism : TEM
R E Mains, B A Eipper

Abstract

Pro-ACTH/endorphin (also called proopiomelanocortin) synthesis in corticotropes and melanotropes continues to serve as a model for investigating the series of enzymatic steps that convert inactive preprohormones to product peptides during transit of the molecules from the rough endoplasmic reticulum through the Golgi and into secretory granules. The complexity of the biosynthesis of bioactive peptides is increased by the widespread occurrence of tissue-specific and developmentally regulated posttranslational processing. Transfection of cDNAs encoding wild-type and mutant preproneuropeptide Y into AtT-20 corticotrope tumor cells revealed the importance of primary sequence in determining the extent of cleavage of the peptide precursor. The purification and cloning of several peptide-processing enzymes, including KEX-1, KEX-2, carboxypeptidase E, and peptidyl-glycine alpha-amidating monooxygenase, have provided important information about intracellular peptide processing, and are beginning to provide information about the sorting of soluble and membrane-associated components of secretory granules.

References

Jan 1, 1990·The Journal of Cell Biology·W S SossinR H Scheller
Aug 1, 1989·Current Opinion in Cell Biology·W B Huttner, S A Tooze
Oct 14, 1988·Biochemical and Biophysical Research Communications·K MizunoH Matsuo
Jan 1, 1988·Annual Review of Physiology·L D Fricker
Jan 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·D A StoffersB A Eipper
Jan 13, 1989·Science·K N ChungH P Moore
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·R J CarrollD F Steiner
Jan 1, 1988·Annual Review of Physiology·B A Eipper, R E Mains
Jun 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·W H Fischer, J Spiess
Jul 1, 1985·The Journal of Clinical Investigation·Y ShibasakiF Takaku

❮ Previous
Next ❯

Citations

Apr 15, 2008·Trends in Endocrinology and Metabolism : TEM·H E Wilson, A White
Oct 21, 2010·Journal of Agricultural and Food Chemistry·Karen WagnerBruce D Hammock
Aug 1, 1993·Clinical Endocrinology·A White, A J Clark
May 31, 1993·Annals of the New York Academy of Sciences·B A EipperR E Mains
May 1, 1996·Metabolism: Clinical and Experimental·M I BorelliJ J Gagliardino
Mar 1, 1997·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S TanakaK Kurosumi
Aug 24, 1999·The Journal of Biological Chemistry·A BruzzanitiR E Mains
Jan 5, 1999·The Journal of Biological Chemistry·E A RatovitskiC J Lowenstein
Feb 1, 2000·The Journal of Biological Chemistry·A M Oyarce, B A Eipper

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.