The TLR3/IRF1/Type III IFN Axis Facilitates Antiviral Responses against Enterovirus Infections in the Intestine.

MBio
Rui SuJianguo Wu

Abstract

Enteroviruses infect gastrointestinal epithelium cells, cause multiple human diseases, and present public health risks worldwide. However, the mechanisms underlying host immune responses in intestinal mucosa against the early enterovirus infections remain elusive. Here, we showed that human enteroviruses including enterovirus 71 (EV71), coxsackievirus B3 (CVB3), and poliovirus 1 (PV1) predominantly induce type III interferons (IFN-λ1 and IFN-λ2/3), rather than type I interferons (IFN-α and IFN-β), in cultured human normal and cancerous intestine epithelial cells (IECs), mouse intestine tissues, and human clinical intestine specimens. Mechanistic studies demonstrated that IFN-λ production is induced upon enterovirus infection through the Toll-like receptor 3/interferon regulatory factor 1 (TLR3/IRF1) signaling pathway in IECs. In turn, the supplementation of IFN-λ subsequently induces intrinsically antiviral responses against enterovirus replication. Notably, intraperitoneal injection in neonatal C57BL/6J mice with mouse recombinant IFN-λ2 protein represses EV71 replication and protects mice from viral lethal effects. Altogether, these results revealed a distinct mechanism by which the host elicited immune responses against ente...Continue Reading

References

Apr 4, 2003·The Journal of Biological Chemistry·Sven HeinzMichael Rehli
Nov 22, 2005·The Journal of General Virology·Ming-Liang LiuChun-Keung Yu
Jun 25, 2010·Journal of Virology·Julia Elisabeth PulvererMario Köster
Apr 27, 2011·Proceedings of the National Academy of Sciences of the United States of America·Johanna PottMathias W Hornef
Aug 19, 2011·Journal of Visualized Experiments : JoVE·Christina M ParkinsonKathleen R Pritchett-Corning
Nov 8, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rachael SiegelGrant Gallagher
Aug 21, 2013·Immunological Reviews·Russell K DurbinJoan E Durbin
Feb 26, 2014·Nature Reviews. Immunology·Lance W Peterson, David Artis
Apr 15, 2014·Current Opinion in Virology·Peng-Nien Huang, Shin-Ru Shih
Jun 24, 2014·Nature Immunology·Charlotte OdendallJonathan C Kagan
Jul 22, 2014·Nature Immunology·Siyuan Ding, Michael D Robek
Apr 24, 2015·Science Translational Medicine·Helen M LazearMichael S Diamond
Jul 23, 2015·Immunity·Helen M LazearMichael S Diamond
Aug 27, 2016·Science·Khalil EttayebiMary K Estes
Feb 1, 2017·Proceedings of the National Academy of Sciences of the United States of America·Coyne G DrummondCarolyn B Coyne
Sep 29, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maolin GeJianguo Wu
Oct 4, 2017·The Journal of Experimental Medicine·Lei SunBruce Beutler
Jan 25, 2018·Viruses·Harshad IngleMegan T Baldridge
Mar 20, 2018·Journal of Visualized Experiments : JoVE·Zhijuan Qiu, Brian S Sheridan
Jul 13, 2018·The Pediatric Infectious Disease Journal·Sally BlackJulian W Tang
Jul 18, 2018·Emerging Infectious Diseases·Veronica CostantiniJan Vinjé
Aug 25, 2018·Science·Margarita Pons-Salort, Nicholas C Grassly
Sep 19, 2018·Emerging Infectious Diseases·Yu LiBenjamin J Cowling
Mar 12, 2019·Science Advances·Charles GoodCarolyn B Coyne
Apr 3, 2019·Nature Microbiology·Emily V MesevAlexander Ploss
Apr 18, 2019·Immunity·Helen M LazearMichael S Diamond

❮ Previous
Next ❯

Methods Mentioned

BETA
IECs
IEC
ELISA
confocal microscopy
PCR
light microscopy
nuclear translocation
enzyme-linked immunosorbent assay

Software Mentioned

GraphPad
Image J
GraphPad Prism

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Nihon rinsho. Japanese journal of clinical medicine
Hiromu Yoshida
Revue médicale de la Suisse romande
E C Bonard
Nordisk medicin
O LAHELLE
Boletín de la Oficina Sanitaria Panamericana
S S KALTER
Saishin igaku. Modern medicine
N Yamada
© 2021 Meta ULC. All rights reserved