The tolerability of rTMS treatment in schizophrenia with respect to cognitive function

Pharmacopsychiatry
M MittrachJ Cordes

Abstract

The purpose of this study was to assess tolerability and safety of high-frequency rTMS with regard to cognitive performance when conducted as "add-on" treatment in chronic schizophrenia in-patients (n=32). Patients, who were on stable antipsychotic treatment, were randomly assigned to verum or sham condition (double-blind). In the verum group, ten sessions of 10 Hz rTMS with a total of 10 000 stimuli were applied over the left dorsolateral prefrontal cortex (PFC) at 110% of motor threshold over a period of two weeks. The sham group received corresponding sham stimulation. RTMS effects on cognitive performance were assessed with a neuropsychological test battery consisting of the following tests: trail making test A and B (TMT), Wisconsin card sorting test (WCST), D2 attention task and the "short test of general intelligence" (KAI). No statistically significant deterioration of cognitive performance was observed as a result of rTMS treatment. Moreover it was shown that in the verum group patients with a less favourable performance on the WCST at baseline tend to improve after rTMS treatment with regard to psychopathology as opposed to patients in the control group. The stability of cognitive function suggests good tolerability o...Continue Reading

Citations

May 17, 2011·Biological Psychiatry·Shawn M McClintockAlvaro Pascual-Leone
Jul 4, 2012·Neuropharmacology·Asli Demirtas-TatlidedeAlvaro Pascual-Leone
Aug 21, 2015·The Cochrane Database of Systematic Reviews·Nadine DougallAndrew McIntosh
May 16, 2019·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·M M PopovV G Kaleda
Jun 11, 2019·Clinical Pharmacology and Therapeutics·Jeanette HuiZafiris J Daskalakis
Jul 28, 2020·Schizophrenia Research. Cognition·Mehmet Diyaddin GülekenÖmer Akil Özer
Apr 13, 2021·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Stephen J BrandtMichael M Francis

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here