PMID: 11328909May 1, 2001Paper

The tolerance and efficacy of interferon-alpha in haemodialysis patients with HCV infection: a multicentre, prospective study

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
F DegosS Chevret

Abstract

A prospective multicentre study was initiated in HCV-infected haemodialysis patients to assess the tolerance and efficacy of alpha-2b interferon. We had planned to include 120 patients with HCV RNA detectable by polymerase chain reaction (PCR) (Amplicor Roche) and histologically documented chronic hepatitis. The dose of alpha-interferon was 3 million units (MU) three times weekly (TTW), to be reduced to 1.5 MU TTW in case of side-effects. Tolerance was evaluated monthly; virological efficacy was evaluated by PCR. A liver biopsy was performed at month 18 (M18). (a) After 37 patients had been included, the study was discontinued by the promoting institution because of severe side-effects requiring that treatment be stopped in 19 patients. The side-effects were: cardiac (4) neuropsychiatric (2), digestive (3), acute necrosis of the graft (1), severe asthenia (9), minor side-effects were observed in 22 patients. A complete 12-month course was completed in 12 patients for the 3 MU TTW dose and in six patients for the 1.5 MU TTW reduced dose. Normal ALT level (OR, 0.16; CI 95%, 0.03-0.89) at inclusion was associated with interruption of treatment (univariate analysis). (b) Sustained virological response was observed in only seven (18...Continue Reading

References

Jun 15, 1990·Annals of Internal Medicine·J B ZeldisP V Holland
Sep 1, 1981·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R G KnodellJ Wollman
May 1, 1994·Kidney International·P KoenigK Gruenewald
Jul 1, 1997·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·T M ChanI K Cheng
Dec 12, 1997·The Journal of Infectious Diseases·J IzopetJ Puel
Dec 24, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P MathurinM O Bitker
Jul 13, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S HuraibA Abdulla

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Citations

Dec 14, 2011·Current Gastroenterology Reports·Mohammad A B Al-FreahMichael A Heneghan
May 6, 2004·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Nasreen KhanLorraine Comanor
Jun 28, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Nassim KamarLionel Rostaing
Oct 2, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Catherine M MeyersJay H Hoofnagle
Apr 14, 2010·Nature Reviews. Nephrology·Fabrizio FabriziPaul Martin
Oct 31, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Doris B Strader
Oct 20, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Mark W RussoViren Joshi
Jan 26, 2011·Journal of Gastroenterology and Hepatology·Chen-Hua Liu, Jia-Horng Kao
Jan 10, 2006·Seminars in Dialysis·Christina M Wyatt, Barbara Murphy
Dec 29, 2010·Hepatitis Research and Treatment·Ashik Hayat, Ahmad Mitwalli
Feb 24, 2004·Drugs·Susan E ChanHugo R Rosen
Aug 1, 2009·Clinical Journal of the American Society of Nephrology : CJASN·Craig E GordonJohn B Wong
Mar 20, 2010·Digestive Diseases and Sciences·Sorin A PetreVijayan Balan
Aug 13, 2013·Clinics and Research in Hepatology and Gastroenterology·Anais Vallet-Pichard, Stanislas Pol
Apr 3, 2004·Gastroentérologie Clinique Et Biologique·Nassim KamarLaurent Alric
Jan 25, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Craig E GordonJohn B Wong
Feb 23, 2008·La Presse médicale·Nabil Ben ChaabaneHammouda Saffar
Oct 2, 2015·Néphrologie & thérapeutique·Anaïs Vallet-Pichard, Stanislas Pol
Oct 27, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Sep 30, 2005·Hemodialysis International·Sydney Tang, Kar Neng Lai
Apr 2, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Doris B StraderUNKNOWN American Association for the Study of Liver Diseases
Dec 5, 2003·Alimentary Pharmacology & Therapeutics·F FabriziP Martin
Apr 6, 2006·Liver International : Official Journal of the International Association for the Study of the Liver·Cristina M RochaMaria Lucia G Ferraz
Nov 15, 2006·Clinical Transplantation·R K SharmaN Prasad
Jan 13, 2006·Gastroenterology·Jules L Dienstag, John G McHutchison
Jul 19, 2005·Clinics in Liver Disease·Fabrizio FabriziPaul Martin
Jan 1, 2013·ISRN Nephrology·Fabrizio Fabrizi
Jan 19, 2011·Journal of Hepatology·Anais Vallet-PichardStanislas Pol
Oct 9, 2012·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Patricia da Silva Fucuta PereiraMaria Lucia Gomes Ferraz
Jul 15, 2011·International Journal of Nephrology·Marco CarboneJames Neuberger
Jul 30, 2008·Journal of Hepatology·Paul Martin, Fabrizio Fabrizi
Jul 23, 2003·The American Journal of Gastroenterology·Mark W RussoRobert S Brown
Aug 30, 2011·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Hye Jin TaeMin Ho Lee
Sep 18, 2008·The American Journal of Gastroenterology·Emuejevoke J OkohStephen A Harrison
Oct 31, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Marina Berenguer
Jul 24, 2012·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Takashi AkibaTadao Akizawa
Sep 28, 2002·Transplantation·Edward Gane, Helen Pilmore
Jan 10, 2003·The International Journal of Artificial Organs·S BunnapradistS Jordan
Jul 16, 2002·The International Journal of Artificial Organs·F FabriziP Martin
Feb 21, 2008·The International Journal of Artificial Organs·A MangiaUNKNOWN Italian Association for The Study of The Liver (A.I.S.F)
Mar 1, 2013·Hepatology International·Aline Gonzalez Vigani

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