The toleration of rat thymocytes to xenogeneic erythrocytes: kinetics of induction and recovery

European Journal of Immunology
J V Bunce, D W Mason

Abstract

The intravenous injection of large doses of xenogeneic erythrocytes into rats completely abrogated the ability of thymocytes from such animals to provide help for antierythrocyte antibody responses in an adoptive transfer system. Thymocyte tolerance developed at a time when the thymocyte donors were producing antibody to the tolerizing antigen, and spleen helper T cells were not tolerized by the injection protocol. A minimum of two injections of 1 ml of packed erythrocytes, spaced 4 - 5 days apart, was required to induce loss of helper activity. Tolerance was fully developed within 16 h of the last injection of antigen. Helper activity recovered over a 24-h period starting 5 days after this injection but could be delayed by giving further injections of antigen. These results suggest that the intrathymic pool of cells with assayable helper activity turns over in about one day and that precursors of this pool are probably also tolerable. Suppressor cells could not be detected in tolerant thymocyte populations indicating that the loss of helper activity was either a consequence of clonal inactivation or that an antigen-specific mechanism existed for the recruitment of helper cells from the thymus. The significance of these finding...Continue Reading

References

Nov 1, 1978·The Journal of Experimental Medicine·G J Nossal, B L Pike
Jan 1, 1979·Immunological Reviews·M Hasek, J Chutná
May 1, 1977·The Journal of Experimental Medicine·S Dorsch, R Roser
Apr 1, 1973·The Journal of Experimental Medicine·W L Elkins
Nov 19, 1974·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·C R Parish, J A Hayward
Jun 18, 1971·Science·E Leckband, E A Boyse
Feb 1, 1974·European Journal of Immunology·J C Jensenius, A F Williams
Jan 1, 1974·Advances in Immunology·K E Hellström, I Hellström
Jul 1, 1967·Physiological Reviews·J F Miller, D Osoba
Aug 1, 1971·Cellular Immunology·H Blomgren, E Svedmyr
Apr 1, 1970·The Journal of Experimental Medicine·J F Miller, G F Mitchell
Aug 1, 1980·European Journal of Immunology·R J BrideauA F Williams
Jan 14, 1964·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·J L GOWANS, E J KNIGHT

❮ Previous
Next ❯

Citations

May 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·M F GoodG J Nossal
Jan 1, 1987·The Journal of Experimental Medicine·D J PatersonA F Williams
Nov 1, 1987·The Journal of Experimental Medicine·D J Paterson, A F Williams
Jan 1, 1983·Immunological Reviews·D W MasonM L Thomas

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.