PMID: 9537368Apr 16, 1998Paper

The TolQRA proteins are required for membrane insertion of the major capsid protein of the filamentous phage f1 during infection

Journal of Bacteriology
E M Click, R E Webster

Abstract

Infection of Escherichia coli by the filamentous bacteriophage f1 is initiated by interaction of the end of the phage particle containing the gene III protein with the tip of the F conjugative pilus. This is followed by the translocation of the phage DNA into the cytoplasm and the insertion of the major phage capsid protein, pVIII, into the cytoplasmic membrane. DNA transfer requires the chromosomally encoded TolA, TolQ, and TolR cytoplasmic membrane proteins. By using radiolabeled phages, it can be shown that no pVIII is inserted into the cytoplasmic membrane when the bacteria contain null mutations in tolQ, -R and -A. The rate of infection can be varied by using bacteria expressing various mutant TolA proteins. Analysis of the infection process in these strains demonstrates a direct correlation between the rate of infection and the incorporation of infecting bacteriophage pVIII into the cytoplasmic membrane.

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Citations

Feb 29, 2000·Journal of Bacteriology·A J Heilpern, M K Waldor
Jan 13, 2016·FEMS Microbiology Letters·Juliano Bertozzi SilvaDominic Sauvageau
Apr 7, 2019·EMBO Reports·Iain D Hay, Trevor Lithgow
Jun 10, 2003·Microbiology and Molecular Biology Reviews : MMBR·Elisabeth GrohmannManuel Espinosa
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Apr 8, 2003·The Journal of Biological Chemistry·Gregor AnderluhJeremy H Lakey
Mar 10, 2007·Microbiology and Molecular Biology Reviews : MMBR·Eric CascalesDanièle Cavard
Oct 23, 2019·Journal of Bacteriology·Poutoum SamireLaetitia Houot
Feb 26, 2020·Infection and Immunity·Mihnea R Mangalea, Breck A Duerkop
Aug 5, 2004·Journal of Bacteriology·James E Bidlack, Philip M Silverman
Dec 11, 2003·Microbiology and Molecular Biology Reviews : MMBR·Hiroshi Nikaido
Jul 27, 2002·Annual Review of Microbiology·Minna M PoranenDennis H Bamford
Dec 15, 2010·Physical Biology·Martin Ploss, Andreas Kuhn
Apr 22, 2016·Journal of Industrial Microbiology & Biotechnology·Konrad KosciowUwe Deppenmeier
Jul 18, 2020·Proceedings of the National Academy of Sciences of the United States of America·Kaitlyn E KortrightPaul E Turner
Nov 2, 2017·Frontiers in Cellular and Infection Microbiology·Jourdan A AnderssonAshok K Chopra
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Dec 24, 2005·Journal of Molecular Biology·Nicholas J Bennett, Jasna Rakonjac

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