The Tomato yellow leaf curl virus (TYLCV) V2 protein inhibits enzymatic activity of the host papain-like cysteine protease CYP1

Biochemical and Biophysical Research Communications
Amalia Bar-ZivYedidya Gafni

Abstract

The viral V2 protein is one of the key factors that Tomato yellow leaf curl geminivirus (TYLCV), a major tomato pathogen worldwide, utilizes to combat the host defense. Besides suppressing the plant RNA silencing defense by targeting the host SGS3 component of the silencing machinery, V2 also interacts with the host CYP1 protein, a papain-like cysteine protease likely involved in hypersensitive response reactions. The biological effects of the V2-CYP1 interaction, however, remain unknown. We addressed this question by demonstrating that V2 inhibits the enzymatic activity of CYP1, but does not interfere with post-translational maturation of this protein.

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Citations

Aug 5, 2016·The New Phytologist·Johana C Misas-VillamilGunther Doehlemann
Feb 24, 2018·International Journal of Molecular Sciences·Anastasia V Balakireva, Andrey A Zamyatnin
Sep 29, 2017·Frontiers in Plant Science·Mercedes Diaz-MendozaManuel Martinez
Aug 18, 2018·The Biochemical Journal·Shuguo HouPing He
May 21, 2020·Frontiers in Microbiology·Ana P Luna, Rosa Lozano-Durán

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