The Tombusvirus-encoded P19: from irrelevance to elegance

Nature Reviews. Microbiology
Herman B Scholthof

Abstract

Since its discovery in the late 1980s, the status of the Tombusvirus-encoded p19 protein (P19) changed from being thought obsolete to its identification a decade later as an important viral pathogenicity factor. The recent finding that P19 suppresses RNA interference (RNAi) by appropriating short interfering RNAs led to its widespread use as an RNAi-probing tool in various plant and animal models. Here, I discuss how our knowledge of p19 has developed over the years, with emphasis on the relevance of understanding its biological roles during Tombusvirus infection of plants.

References

Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·D M Rochon
Apr 1, 1989·Virology·D M Rochon, J H Tremaine
Sep 1, 1989·The Journal of General Virology·F GriecoM Russo
Jan 1, 1994·Advances in Virus Research·M RussoG P Martelli
Jun 1, 1993·Virology·T DalmayM Russo
Oct 28, 1998·Proceedings of the National Academy of Sciences of the United States of America·R AnandalakshmiV B Vance
Nov 26, 1999·Proceedings of the National Academy of Sciences of the United States of America·O VoinnetD C Baulcombe
Sep 8, 2001·The Journal of Biological Chemistry·I R ChoiK A White
Aug 2, 2002·Journal of Personality and Social Psychology·Jay G HullAmanda R Matthews
Jan 30, 2003·The EMBO Journal·György SzittyaJózsef Burgyán
Mar 1, 2003·The Plant Journal : for Cell and Molecular Biology·Olivier VoinnetDavid Baulcombe
Jul 15, 2003·Plant Physiology·István PappAntonius J M Matzke
Dec 31, 2003·Cell·Jeffrey M VargasonTraci M Tanka Hall
Jan 28, 2004·Proceedings of the National Academy of Sciences of the United States of America·Wan-Xiang LiShou-Wei Ding
Feb 21, 2004·The EMBO Journal·Lóránt LakatosJózsef Burgyán
Mar 17, 2004·PLoS Biology·Zhixin XieJames C Carrington
Mar 19, 2004·Current Biology : CB·Phillip D Zamore
Apr 8, 2004·Virus Research·Braden M RothVicki B Vance
Apr 15, 2004·Current Opinion in Neurobiology·Elizabeth A Phelps
Apr 23, 2004·Trends in Plant Science·Dániel Silhavy, József Burgyán

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Citations

Jun 6, 2008·Plant Molecular Biology·M Lucrecia AlvarezGuy A Cardineau
Jul 9, 2009·Journal of the American Chemical Society·Ingrid M van der WielJohn Paul Pezacki
May 20, 2009·Genes & Development·Jennifer L Umbach, Bryan R Cullen
May 25, 2011·Plant Physiology·Herman B ScholthofPeter Moffett
Nov 16, 2010·Biochemistry. Biokhimii︠a︡·R T Omarov, R I Bersimbai
Apr 10, 2007·Annual Review of Phytopathology·James N Culver, Meenu S Padmanabhan
Dec 18, 2010·BMC Biotechnology·Zun Liu, Christopher M Kearney
Jun 26, 2007·PLoS Pathogens·Joost HaasnootBen Berkhout
Jan 25, 2007·Proceedings of the National Academy of Sciences of the United States of America·Rustem T OmarovHerman B Scholthof
Apr 10, 2010·Journal of Oncology·Manmeet S Ahluwalia, Candece L Gladson
Feb 5, 2013·FEBS Letters·Dana C Danielson, John Paul Pezacki
May 21, 2015·Pharmaceutical Biology·Sara MohammadzadehParastoo Ehsani
Apr 13, 2010·Journal of Biotechnology·Zun Liu, Christopher M Kearney
Jun 16, 2009·Seminars in Cell & Developmental Biology·Veria Alvarado, Herman B Scholthof
Jul 3, 2009·The Journal of General Virology·Rennos FragkoudisAlain Kohl
Apr 6, 2016·Molecular Therapy. Nucleic Acids·Dana C DanielsonJohn Paul Pezacki
Jan 29, 2011·Virology·Jessica J CiomperlikHerman B Scholthof
Mar 1, 2011·Journal of Molecular Biology·Renata A RawlingsNils G Walter
Nov 30, 2014·Molecular Biotechnology·Yiyang ZhouChristopher M Kearney
Jan 7, 2015·Plant Molecular Biology·Jorge A Salazar-GonzálezSergio Rosales-Mendoza
May 30, 2016·Archives of Virology·Sridhar JarugulaLucy R Stewart

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