The TORCH (towards a revolution in COPD health) survival study protocol

The European Respiratory Journal
J Vestbo, TORCH Study Group

Abstract

Only long-term home oxygen therapy has been shown in randomised controlled trials to increase survival in chronic obstructive pulmonary disease (COPD). There have been no trials assessing the effect of inhaled corticosteroids and long-acting bronchodilators, alone or in combination, on mortality in patients with COPD, despite their known benefit in reducing symptoms and exacerbations. The "TOwards a Revolution in COPD Health" (TORCH) survival study is aiming to determine the impact of salmeterol/fluticasone propionate (SFC) combination and the individual components on the survival of COPD patients. TORCH is a multicentre, randomised, double-blind, parallel-group, placebo-controlled study. Approximately 6,200 patients with moderate-to-severe COPD were randomly assigned to b.i.d. treatment with either SFC (50/500 microg), fluticasone propionate (500 microg), salmeterol (50 microg) or placebo for 3 yrs. The primary end-point is all-cause mortality; secondary end-points are COPD morbidity relating to rate of exacerbations and health status, using the St George's Respiratory Questionnaire. Other end-points include other mortality and exacerbation end-points, requirement for long-term oxygen therapy, and clinic lung function. Safety ...Continue Reading

Citations

Aug 25, 2005·Archivos de bronconeumología·J L Izquierdo Alonso, R Arroyo-Espliguero
Feb 23, 2007·The New England Journal of Medicine·Klaus F Rabe
Feb 23, 2007·The New England Journal of Medicine·Peter M A CalverleyUNKNOWN TORCH investigators
Jun 15, 2006·Respirology : Official Journal of the Asian Pacific Society of Respirology·Tawimas ShaipanichStephen Lam
Jan 29, 2011·Respirology : Official Journal of the Asian Pacific Society of Respirology·Martin MacDonaldPhilip G Bardin
Feb 22, 2007·Thorax·Lorcan P McGarveyUNKNOWN TORCH Clinical Endpoint Committee
May 1, 2007·Thorax·Michael Rudolf
May 20, 2005·American Journal of Respiratory and Critical Care Medicine·Victor A KiriJørgen Vestbo
Jan 21, 2006·American Journal of Respiratory and Critical Care Medicine·Neil C BarnesUNKNOWN SCO30005 Study Group
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Dec 1, 2007·International Journal of Chronic Obstructive Pulmonary Disease·David M Mannino, Victor A Kiriz
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Sep 3, 2011·Lung India : Official Organ of Indian Chest Society·Parthasarathi BhattacharyyaSujan Bardhan
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