The torso receptor localizes as well as transduces the spatial signal specifying terminal body pattern in Drosophila

Nature
J Casanova, G Struhl

Abstract

Specification of the end portions of the Drosophila body depends on the torso (tor) protein, a receptor tyrosine kinase that accumulates uniformly along the entire surface of the embryo but is activated only in the vicinity of the poles. Several genes are normally required for activating tor and appear to define a system in which a gene product tethered to the extracellular vitelline membrane at each end of the egg provides a local source for an extracellular tor ligand. This ligand would have to diffuse from the membrane to the cell surface of the embryo without losing its spatial localization. Here we report that the failure to accumulate tor protein at one or both poles leads to spatially inappropriate activity of more centrally located receptor. This ectopic activity depends on the same gene functions normally required for activating tor; thus we infer that it reflects inappropriate diffusion of the ligand to more central regions of the body. We conclude that the receptor not only transduces the spatial signal imparted by the tor ligand, but also ensures its correct localization by sequestering the ligand. Ligand trapping by receptor may also localize spatial signals in other patterning systems, including specification of t...Continue Reading

References

Apr 6, 1989·Nature·F SprengerC Nüsslein-Volhard
Jul 1, 1986·Roux's Archives of Developmental Biology : the Official Organ of the EDBO·Trudi Schüpbach, Eric Wieschaus

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Citations

Jun 19, 1998·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·E Bier
Jan 3, 2001·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·U Schmidt-Ott
Mar 14, 1995·Biochimica Et Biophysica Acta·A J Courey, J D Huang
Nov 1, 1996·Trends in Genetics : TIG·R Rivera-Pomar, H Jäckle
Oct 1, 1994·Mechanisms of Development·J CasanovaG Struhl
Feb 18, 2004·Biophysical Chemistry·Alexander M BerezhkovskiiStanislav Y Shvartsman
Jul 20, 2002·Seminars in Cell & Developmental Biology·Kenneth M Cadigan
Feb 13, 2001·Current Opinion in Plant Biology·S E Clark
Dec 9, 2000·Biochimica Et Biophysica Acta·R K Mann, P A Beachy
Aug 1, 1994·Zygote : the Biology of Gametes and Early Embryos·C L Saxe
Jan 17, 2009·Proceedings of the National Academy of Sciences of the United States of America·Alexander M BerezhkovskiiStanislav Y Shvartsman
Aug 30, 1994·Proceedings of the National Academy of Sciences of the United States of America·U Schmidt-OttG M Technau
Jun 3, 2006·Science·Michael A Crickmore, Richard S Mann
Jun 11, 2004·Annual Review of Biochemistry·Randall K Mann, Philip A Beachy
Oct 22, 2009·Mathematical Modelling of Natural Phenomena·Hans G OthmerChuan Xue
Jul 8, 2008·Current Opinion in Genetics & Development·Stanislav Y ShvartsmanAlexander M Berezhkovskii
Feb 11, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Willis X Li
Oct 29, 2004·The EMBO Journal·Einat CinnamonZe'ev Paroush
Jun 27, 2013·Wiley Interdisciplinary Reviews. Developmental Biology·Stanislav Y Shvartsman, Ruth E Baker
Feb 1, 1994·Current Opinion in Genetics & Development·B Dickson, E Hafen
Aug 1, 1993·Current Opinion in Genetics & Development·M Hoch, H Jäckle
Jan 24, 2006·Journal of Theoretical Biology·Filipa Alves, Rui Dilão
Mar 24, 1998·Mechanisms of Development·M FurriolsJ Casanova
Jul 5, 2003·Current Biology : CB·Ellen K LeMosy
Jun 24, 2008·Current Biology : CB·Mathieu CoppeyStanislav Y Shvartsman
Jun 20, 2003·Current Biology : CB·Leslie M StevensDavid Stein
Aug 8, 2006·Developmental Cell·Lea A GoentoroStanislav Y Shvartsman
Nov 16, 2007·Developmental Biology·Mathieu CoppeyStanislav Y Shvartsman
Jun 29, 2005·Developmental Biology·Gregory T ReevesStanislav Y Shvartsman
Apr 23, 2017·Genesis : the Journal of Genetics and Development·Natália Martins FeitosaRodrigo Nunes da Fonseca
Apr 14, 2006·Molecular and Cellular Biology·Erica Morán, Gerardo Jiménez

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