The total synthesis of an aurone isolated from Uvaria hamiltonii: aurones and flavones as anticancer agents

Bioorganic & Medicinal Chemistry Letters
N J LawrenceJ A Hadfield

Abstract

The naturally occurring aurone 1, isolated from Uvaria hamiltonii, and a series of aurones analogues based structurally on known tubulin binding agents were prepared and evaluated for anticancer activity. Aurone 20 was the most active (IC(50) K562 50 nM) and caused significant G2/M cell-cycle arrest.

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Citations

Feb 27, 2015·Journal of Enzyme Inhibition and Medicinal Chemistry·Seref DemirayakIsmail Kayagil
Jun 7, 2014·Pharmacological Reports : PR·Jian ZhangShi-Xing Qiao
Aug 30, 2008·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Hong-May SimMei Lin Go
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Feb 22, 2020·Beilstein Journal of Organic Chemistry·Alexander SailerOliver Thorn-Seshold
Oct 18, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Phuong Thuy Viet NguyenCam-Van Thi Vo

Related Concepts

Parent of thiazolyl blue
Aurone
Antineoplastic Agents, Phytogenic
Diphenylbenzofuran
Cell Cycle
DNA, Neoplasm
Bioflavonoids
Indicators
M Phase, Mitotic
Plasma Protein Binding Capacity

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