The total synthesis of calcium atorvastatin

Organic & Biomolecular Chemistry
Luiz C DiasEliezer J Barreiro

Abstract

A practical and convergent asymmetric route to calcium atorvastatin (1) is reported. The synthesis of calcium atorvastatin (1) was performed using the remote 1,5-anti asymmetric induction in the boron-mediated aldol reaction of β-alkoxy methylketone (4) with pyrrolic aldehyde (3) as a key step. Calcium atorvastatin was obtained from aldehyde (3) after 6 steps, with a 41% overall yield.

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Citations

Dec 14, 2016·Organic Letters·Naoya SagawaSeijiro Hosokawa
Feb 22, 2017·The Journal of Organic Chemistry·Luiz C Dias, Emilio C de Lucca
Aug 11, 2016·Organic & Biomolecular Chemistry·Damian E YerienAl Postigo
May 10, 2018·Anais Da Academia Brasileira De Ciências·Ronaldo A Pilli, Francisco F DE Assis
Mar 21, 2019·ACS Medicinal Chemistry Letters·Tryfon Zarganes-TzitzikasAlexander Dömling

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